Factors related to cervicogenital high-risk human papillomavirus persistence among Chinese women: a nationwide multi-center cohort study

作者：Jing Li, Chong-Bi Huang, Fan Zhao, Dandan Zhao, Mengyin Ao, Shaokai Zhang, Zhi-Fang Li, Leni Kang, You‐Lin Qiao, Wen Chen, Yin Liu, Lian Xu, Xi Zeng, Mingwei Yuan, Shao-Long Xue, Shuyuan Liu, Mingrong Xi, Guangdong Liao · 发表于：Virology Journal · 年份：2025 · DOI：10.1186/s12985-025-03047-4 · 被引用次数：3 · 研究领域：Cervical Cancer and HPV Research、Head and Neck Cancer Studies、Reproductive tract infections research

BACKGROUND: Persistent infection with high-risk human papillomavirus (HR-HPV) is a necessary cause of cervical cancer and its precancerous lesions. This study aimed to identify factors associated with HR-HPV persistence in Chinese women. METHODS: This study is a population-based, nationwide, multi-center prospective cohort study initiated in 2017, and a total of 10,481 women undergoing cervical cancer screening were enrolled. A subset of 1,684 women who tested HR-HPV positive at baseline were included in the analysis. The results of their HPV testing at baseline and during three follow-up visits (2018-2020) were used to assess 1-, 2-, and 3-year HR-HPV persistence. Variables with statistically significant associations in univariate analyses, expressed as odds ratios (ORs) with 95% confidence intervals (CIs), were subsequently entered into a stepwise multivariate logistic regression model to identify independent predictors of HR-HPV persistence. RESULTS: The mean age of 1,684 HPV-positive women at baseline was 47.6 ± 9.5 (interquartile range (IQR) = 42-54) years. The most prevalent genotypes at baseline were HPV52 (28.3%), HPV16 (20.2%), HPV58 (17.8%), HPV33 (6.7%), and HPV18 (6.2%). Overall HR-HPV persistence rates declined over time were 66.8% at 1 year, 48.3% at 2 years, and 39.9% at 3 years. Infection with HPV33 (OR = 2.40, 95% CI: 1.42-4.01), HPV52 (OR = 1.95, 95% CI: 1.45-2.64), or HPV58 (OR = 2.01, 95% CI: 1.40-2.88), as well as postmenopausal status (OR = 2.84, 95% CI:...