Diabetes as an independent risk factor for severe inflammatory bowel disease: evidence from an inflammation–metabolism–liver coupling framework

作者：Bin Huang, Honglin An, Liming Chen, Yiman Qiu, Yaping Su, Shiju Shen, Huaping Wu, Mengyuan Li, Lisha Lu, Rong Wang, Hangju Hua, Wujin Chen · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1707507 · 被引用次数：3 · 研究领域：Liver Disease Diagnosis and Treatment、Inflammatory Bowel Disease、Gut microbiota and health

Background The clinical course of inflammatory bowel disease (IBD) varies widely, and identifying factors associated with severe disease is essential for risk stratification. Diabetes has been proposed as a potential determinant of adverse outcomes, yet its independent role in disease progression remains unclear. Methods We retrospectively analyzed clinical data from patients with mild and severe IBD. Demographic, inflammatory, hepatic, and metabolic parameters were compared between groups. Logistic regression was used to identify independent predictors of severe IBD. Model performance was assessed using receiver operating characteristic curves, calibration analysis, and cross-validation. An inflammation–metabolism–liver coupling index (IMLCI) was constructed to integrate key predictors. Results Patients with severe IBD exhibited significantly higher levels of inflammatory markers (WBC, neutrophil percentage, CRP), impaired hepatic function indices (ALT, AST, bilirubin), and adverse metabolic profiles (elevated TG and LDL, reduced HDL and vitamin B12). Diabetes was strongly associated with severe IBD (odds ratio = 3.81, P < 0.001), confirming its independent effect beyond traditional risk factors. The inflammation–metabolism–liver coupling index (IMLCI) demonstrated excellent discrimination (AUC = 0.900 in the training cohort and 0.891 in the testing cohort), good calibration (Hosmer–Lemeshow P = 0.83), and robust internal validation, outperforming single laboratory or...