Multidisciplinary Team Support for Patients With Head and Neck Cancer Receiving Radiotherapy

作者：Yiyan Pei, Jingjing Wang, Juejin Li, Ye Chen, Jinlan He, Zhigong Wei, Zheran Liu, Yonglin Su, Tingting Dai, Li Yin, Yaotiao Deng, Jitao Zhou, Hangrui Tian, Yunhuan Li, Xiaoli Chen, Shu Zhang, Yang Chen, Qianwen Yan, Ruidan Li, Zheng Jiang, Xiaolin Hu, Xingchen Peng · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.47590 · 被引用次数：6 · 研究领域：Advances in Oncology and Radiotherapy、Head and Neck Cancer Studies、Cancer survivorship and care

Importance: Guidelines recommend nutritional, psychological, and rehabilitation support for patients with head and neck cancer during radiotherapy, but many patients, particularly in China, lack efficient access to such services. Objective: To assess the effectiveness of Supportive Holistic Interventions by Nurses and Experts via Multidisciplinary Team (SHINE-MDT), a framework to coordinate nutritional, psychological, and rehabilitation support, at reducing radiotherapy interruptions, improving nutritional status, alleviating psychological burdens, and enhancing the quality of life (QOL) among patients with head and neck cancer undergoing radiotherapy. Design, Setting, and Participants: A randomized clinical trial (RCT) of SHINE-MDT vs usual care (UC) was conducted at West China Hospital from April 27 to December 1, 2023. Adult patients aged 18 years or older with head and neck cancer undergoing radiotherapy were enrolled. Interventions: Eligible patients were randomly allocated (1:1) to either UC or SHINE-MDT. The SHINE-MDT group received nutritional, psychological, and rehabilitation support delivered by a team including oncology nurse specialists, radiation and medical oncologists, dietitians, psychotherapists, and rehabilitation physicians. The UC group received supportive measures aligned with standard practice. Main Outcomes and Measures: The primary outcome was the radiotherapy interruption rate in the intent-to-treat population. Secondary outcomes included patient-rep...