A prognostic model based on gamma-glutamyl transpeptidase-derived neutrophil-platelet for predicting intrahepatic recurrence in hepatocellular carcinoma

作者：Zhixiao Huo, Lihua Yan, Wentao Kuai, Wei Liu, Kunyan Qiao, Qinghai Dai, Bei Jiang, JianXu, Yu Cao, Kai Ye, Liang Xu, Rui Su · 发表于：Discover Oncology · 年份：2025 · DOI：10.1007/s12672-025-03997-9 · 被引用次数：2 · 研究领域：Hepatocellular Carcinoma Treatment and Prognosis、Inflammatory Biomarkers in Disease Prognosis、Organ Transplantation Techniques and Outcomes

AIMS: This study aims to investigate the prognostic significance of the combined GNR and GPR in patients with early-stage hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC). METHODS: Retrospective analysis was performed on clinical data of 145 HBV-infected patients with early-stage HCC (ESHCC) who underwent radiofrequency ablation (RFA) and/or surgical resection. Patients were randomly allocated to training (n = 103) and validation (n = 42) cohorts for further survival analysis and model verification. The area under the receiver operating characteristic curves (ROC) was used for evaluating the diagnostic performance of ERM-model. And at the optimal cutoff, a survival analysis on all patients was conducted. Simultaneously, all patients were divided into different subgroups to evaluating ERM-Model. RESULTS: Multivariate Cox analysis identified GNR and GPR as independent risk factors for postoperative intrahepatic recurrence (IHR). The combined biomarkers panel demonstrated superior diagnostic accuracy (AUC = 0.812) compared to AFP (AUC = 0.773). Survival analysis showed a significantly higher 2-year cumulative non-IHR rate in the low-risk group (logit(P) < 0.398) verus the high-risk group (logit(P) ≥ 0.398, p < 0.001). Subgroup analysis of all patients that ERM-model showed differencesin HCC stage stratification, with higher diagnostic accuracy for BCLC stage A cases compared to BCLC stage 0 cases. CONCLUSIONS: GNR and GPR are valuable predictors of IHR in ESHCC. C...