Associations between the triglyceride glucose-body roundness index and frailty trajectory in populations with cardiovascular–kidney–metabolic syndrome: a nationwide prospective cohort study

作者：Zhongmin Fu, Shulin Song, Yan Ji, Lisi Duan, Ziyan Wang, Yue Chen, Yinning Guo, Kang Zhao, Xinyi Xu, Changqing Wang, Qin Xu · 发表于：The Journals of Gerontology Series A · 年份：2025 · DOI：10.1093/gerona/glaf273 · 被引用次数：4 · 研究领域：Frailty in Older Adults、Chronic Kidney Disease and Diabetes、Dialysis and Renal Disease Management

BACKGROUND: Frailty is a key intervention target for older adults with cardiovascular-kidney-metabolic (CKM) syndrome. Evidence suggests that the triglyceride glucose (TyG) index and body roundness index (BRI) are associated with frailty; however, the predictive value of their combination (TyG-BRI) remains unclear. METHODS: We analyzed data from 3687 middle-aged and older adults with CKM syndrome in the China Health and Retirement Longitudinal Study (CHARLS, 2011-2020). The frailty index serving as the outcome variable was constructed based on 30 multidimensional health deficit items. The primary exposure, the TyG-BRI index, was calculated as the product of the TyG index and the BRI. Latent growth mixture modeling was employed to identify frailty trajectories. Multivariable adjusted logistic regression was conducted to explore the association between TyG-BRI and frailty trajectories. Subgroup analyses were performed to elucidate the interactions among these factors further. RESULTS: Three distinct frailty trajectories emerged: pre-frailty to frailty deterioration (18.8%), persistent frailty (53.7%), and pre-frailty transition to health (27.4%). The highest TyG-BRI quartile was associated with a higher risk of pre-frailty to frailty deterioration than the lowest quartile (OR = 2.229, 95% CI, 1.137-4.367). Subgroup analysis indicated a significant interaction between age and the association of TyG-BRI with frailty trajectories (p = .041), suggesting the need for age-specific in...