Type 2 inflammation in chronic obstructive pulmonary disease: A promising treatable trait and practice recommendations

作者：Yan Chen, Ting Yang, Jing Zhang, Xiangqi Chen, Xin Chen, Zhe Cheng, Yaqing Li, Xiaoyun Fan, Wei Han, Zhiyi He, Dedong Ma, Ying Meng, Junxia Yan, Yan Yin, Huihui Zeng, Qiong Zhou, Xiaoming Zhou, Hui Cai, Yanan Cui, Yiming Ma, Fuqiang Wen, Yongchang Sun, Dejun Sun, Xiaoju Liu, Jinping Zheng, Wei Wang, Zeguang Zheng, Xixin Yan, Shaoxi Cai, Jie Cao, Yuanlin Song, Jianping Zhao, Yumin Zhou, Huili Zhu, Manxiang Li, Yanfei Guo, Qianli Ma, Zhenyu Liang, Li Zhao, Yahong Chen, Jianmiao Wang, Fengyan Wang, Yuqiong Yang, Huajing Yang, Jian Kang, Rongchang Chen · 发表于：Chinese Medical Journal - Pulmonary and Critical Care Medicine · 年份：2025 · DOI：10.1016/j.pccm.2025.11.004 · 被引用次数：2 · 研究领域：Chronic Obstructive Pulmonary Disease (COPD) Research、Respiratory Support and Mechanisms、Inflammation biomarkers and pathways

Background: Type 2 inflammation is a key inflammatory endotype of chronic obstructive pulmonary disease (COPD). The precise identification and targeted intervention of treatable traits related to type 2 inflammation are crucial directions in the current management of COPD. Recently, a growing body of evidence-based medical data has accumulated regarding the clinical characteristics, biomarkers, therapeutic agents, and efficacy evaluation of type 2 inflammation in COPD, providing strong support for clinical diagnosis and treatment. This clinical practice recommendation systematically reviewed the evidence-based medical literature and integrated clinical experience to present expert opinions, aiming to standardize and improve the management of type 2 inflammation in COPD. Methods: This clinical practice recommendation followed Appraisal of Guidelines for Research and Evaluation II (AGREE II) and the Reporting Items for Practice Guidelines in HealThcare (RIGHT) statement to ensure the thoroughness and transparency. Clinical questions were primarily derived from surveys among experts in the field and thorough discussion at meetings. The evidence grading levels and recommendation grades adopted in the clinical practice recommendation follow the evidence grading levels and recommendation grades established by the Oxford Centre for Evidence-Based Medicine. The expert opinions were formulated through open discussion and expert voting. Expert opinions with an agreement rate of 80 % or...