Advanced injectable Ti₃C₂ MXene hydrogel: A multifunctional solution for diabetic alveolar bone defect repair

作者：Yue Yan, Yifan Li, Zijiang Yang, Hai Xu, Jia Yan, Hanbang Chen, Xufeng Chen, Yuanyuan Wang, Shijia Tang, Feimin Zhang · 发表于：Chemical Engineering Journal · 年份：2025 · DOI：10.1016/j.cej.2025.171850 · 被引用次数：4 · 研究领域：Nanoplatforms for cancer theranostics、Graphene and Nanomaterials Applications、Advanced Nanomaterials in Catalysis

Diabetes mellitus creates significant challenges for alveolar bone repair due to oxidative stress-induced immune dysregulation, and chronic hyperglycemia induced- increased infection susceptibility. The irregular alveolar bone defects further limits conventional bone repair approaches, as traditional grafts and rigid scaffolds lack adaptability for proper integration in these challenging sites. MXene nanosheets have emerged as promising candidates due to their exceptional reactive oxygen species (ROS) scavenging capabilities and remarkable photothermal conversion efficiency, enabling antibiotic-free antimicrobial therapy. Hydrogel systems offer complementary advantages through injectability, self-healing capacity, and superior tissue adhesion. However, integration of MXene nanosheets within dynamically crosslinked hydrogel networks for diabetic bone repair remains largely unexplored. Therefore, we developed an innovative double-crosslinked, injectable, self-healing hydrogel system incorporating MXene nanosheets, designed to target interconnected pathological processes in diabetic alveolar bone defects. Our multifunctional approach addresses three critical objectives: First, exceptional injectability, self-healing and tissue adhesion properties enable precise adaptation to irregular defect geometries with stable retention and inherent tissue adhesion. Second, incorporated MXene nanosheets function as efficient ROS scavengers, restoring local immune homeostasis and counteractin...