Age-related alterations in regional cerebrovascular reactivity: mediation by grey matter atrophy and association with cognitive performance

作者：Jiajia Zhang, Xuejia Jia, Qihui Wang, Yifei Zhang, Xiuqin Jia, Qi Yang · 发表于：Age and Ageing · 年份：2025 · DOI：10.1093/ageing/afaf353 · 被引用次数：1 · 研究领域：Dementia and Cognitive Impairment Research、Functional Brain Connectivity Studies、Advanced MRI Techniques and Applications

BACKGROUND: Although cerebrovascular reactivity (CVR) correlates with cognitive performance in neurodegenerative conditions, the age-related spatial patterns of CVR alterations and their relationships with grey matter (GM) atrophy and cognition are underexplored. METHODS: In this cross-sectional study, 301 cognitively unimpaired participants (181 younger, 18-34 years; 120 older: 60-89 years) underwent multi-echo resting-state functional magnetic resonance imaging (fMRI) for CVR measurement. Voxel-wise t-tests compared regional CVR between age groups, with significant clusters defined as regions of interest (ROIs). Mediation analyses examined regional GM atrophy as a mediator of the ageing-CVR relationships within ROIs. Multivariable linear regression and restricted cubic spline analyses evaluated the association between ROI-CVR and cognition in older adults. RESULTS: Compared with younger adults, older adults showed lower CVR primarily in the temporal, basal ganglia, cingulate, brainstem and cerebellum regions, while higher CVR in the frontal, parietal, occipitotemporal, thalamus and caudate regions. Regional GM atrophy partially mediated age-related CVR increases in the right frontal pole (P = .004) and fusiform/lingual gyrus (P = .001), as well as age-related CVR reduction in bilateral brainstem/cerebellum vermis 45 (P < .001). The proportions mediated were 55.9%, 56.6% and 79.2%, respectively. Among older adults, six ROI-CVRs were associated with executive function, exhibi...