Design Principles, Synthetic Strategies, and Biomedical Applications of Peptide–Polymer Conjugates

作者：Zhuoran Yang, Zhonghao Li, Xingjun Zhao, Kehan Du, Juntang Lin, Hao Jiang, Jintao Zhu · 发表于：Polymer science & technology. · 年份：2025 · DOI：10.1021/polymscitech.5c00115 · 被引用次数：7 · 研究领域：Advanced Polymer Synthesis and Characterization、Supramolecular Self-Assembly in Materials、Chemical Synthesis and Analysis

stability and short half-life limit the practical applications. Peptide-polymer conjugates, by linking peptides with synthetic or natural polymeric materials, significantly improve their pharmacokinetic properties and therapeutic efficacy. This review systematically summarizes the design principle and synthetic strategies of conjugates, including covalent bonding, physical association, and self-assembly mechanisms, and elaborates on their applications in drug delivery, immunotherapy, and tissue engineering. The review also discusses current challenges, such as difficulties in controlling conjugation sites and increased immunogenicity, and envisions the development of responsive intelligent systems to provide a theoretical basis and reference for future clinical translation of peptide-based therapeutics.