Health-related quality of life and psychosocial outcomes in long-term survivors treated with immune checkpoint inhibitors: a nationwide multicenter study

作者：Taha Koray Şahin, Fatih Atalah, Bahadır Köylü, Ahmet Fatih Oruç, Aydın Acarbay, Akgün Karakök, S. Dogan, Cevat İlteriş Kıkılı, Görkem Turhan, Gamze Emin, Sebahattin Çelik, İlknur Deliktaş Onur, Tuba Ugur Tuzcu, Sedat Biter, Safa Can Efil, Fadime Sinem Ardic, Azer Gokmen, Halil Göksel Güzel, Kadriye Erkan Turan, Ahmet Kürsad Disli, Salih Tünbekici, Erdem Göker, Mevlüde İnanç, Özlem Çınar Özdemir, Banu Öztürk, Muslih Ürün, Arzu Yaşar, Mehmet Alı Nahıt Şendur, İsmail Oğuz Kara, Osman Sütçüoğlu, Öztürk Ateş, Tülay Eren, Atila Yıldırım, Saadettin Kılıçkap, Ömer Dızdar, Fatma Alev Türker, Mustafa Erman, Mehmet Artaç, Fatih Selçukbırıcık, Sercan Aksoy, Deniz Can Güven · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1693295 · 被引用次数：2 · 研究领域：Cancer Immunotherapy and Biomarkers、Cancer survivorship and care、Tryptophan and brain disorders

Background: The increasing use of immune checkpoint inhibitors (ICIs) has resulted in a growing population of long-term survivors (LTS). However, the long-term psychosocial and quality of life (QoL) outcomes in these patients remain underexplored. This study aimed to evaluate QoL, psychological morbidity, fear of cancer progression (FoP), and functional outcomes in cancer patients treated with ICIs for at least six months without disease progression. Methods: This cross-sectional, multicenter study included 346 adult cancer patients from 17 tertiary oncology centers in Türkiye. Participants had received ICIs for ≥6 months in (neo)adjuvant or metastatic settings. Standardized questionnaires assessed QoL, psychological distress, FoP, immune-related adverse events (irAEs), and work status. Results: The median age of the cohort was 62 years (IQR: 53-69). Average survivor QoL was comparable to the Turkish general population; but 119 (34.5%) survivors had poor QoL. Clinically relevant symptoms of depression and anxiety were present in 24.3% and 20.8% of patients, respectively, while 48% reported FoP. The overall return-to-work rate among patients initially employed was 50.9%, with 72.7% returning within the first year. Depression, anxiety, and FoP were negatively correlated with all QoL domains. All grade irAEs were common (53.8%) but not significantly associated with worse QoL (p=0.149). Conclusions: This study represents one of the largest cohorts to date evaluating survivorship ...