Platelet-to-Hemoglobin Ratio in Predicting Major Adverse Cardiovascular Events After Coronary Artery Bypass Grafting

作者：Shanghao Chen, Kefan Zhang, Xuantao Liu, Zhihao Yang, Xiang Guan, Xin Zhou, Junwen Xiao, Xiaofang Li, Jing Jin, Xiaochun Ma, Qingguo Li · 发表于：Vascular Health and Risk Management · 年份：2025 · DOI：10.2147/vhrm.s562298 · 被引用次数：1 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Antiplatelet Therapy and Cardiovascular Diseases、Blood transfusion and management

Purpose: Coronary artery bypass grafting (CABG) is widely recognized as the gold standard treatment for patients with complex coronary artery disease (CAD). The identification of reliable hematologic predictors for major adverse cardiovascular events (MACE) after CABG remains limited. In recent years, the platelet-to-hemoglobin ratio (PHR) has emerged as a promising prognostic marker in various cardiovascular conditions and malignancies. This study investigated the prognostic value of the PHR for predicting in-hospital and short-term adverse outcomes after CABG. Patients and Methods: This retrospective cohort study included 1672 Chinese patients who underwent isolated CABG surgery between 2015 and 2021. PHR was calculated as platelet count (× 10 9 /L) divided by hemoglobin (g/L). The primary endpoint was 3-point MACE (3P-MACE), including cardiovascular death, nonfatal myocardial infarction, or nonfatal stroke during hospitalization. A predictive nomogram was developed and validated using bootstrap resampling. Results: In our study, individuals with elevated PHR levels were more likely to experience 3P-MACE and stroke. After propensity matching, the incidence of 3P-MACE was 5.7% in the high PHR group (PHR≥ 1.890) and 1.5% in the low PHR group ( P = 0.010). Multivariate analysis identified preoperative PHR (odds ratio: 1.800 [95% CI 1.073– 3.021], P =0.026) as an independent predictor for 3P-MACE post-CABG. A predictive nomogram for 3P-MACE following CABG was successfully devel...