Integrating network pharmacology, molecular docking and experimental validation to explore therapeutic targets for alleviating allergic rhinitis with anxiety and depressive behaviors

作者：Yiyi Lin, Shihan Liu, Zhiquan Zhu, Jin Yang, Pan Huang, Yuyang Liu, Wenlong Luo · 发表于：RSC Advances · 年份：2025 · DOI：10.1039/d5ra09128d · 被引用次数：2 · 研究领域：Olfactory and Sensory Function Studies、Allergic Rhinitis and Sensitization、Dermatology and Skin Diseases

, animal experiments confirmed that XCHD ameliorated neuroinflammation in the olfactory bulb based on restoration of the nasal mucosal barrier. Behavioral experiments further verified that XCHD alleviated depression behavior and olfactory impairment in mice. Combined with the molecular docking results and component target screening, the experimental results indicate that XCHD is critical in treating AR and is expected to be a candidate for treating impaired olfactory function and depression.