Hydrocortisone in Preterm Infants and School-Age Functional Outcomes

作者：Sara B. DeMauro, Haresh Kirpalani, Susan R. Hintz, Kristi L. Watterberg, Victoria E. Watson, Jean Lowe, Seetha Shankaran, Sanjay Chawla, Betty R. Vohr, Michael E. Msall, Carl T. D’Angio, Bradley A. Yoder, Khanh Lai, Sarah Winter, Tarah T. Colaizy, Stephanie L. Merhar, Kristina Ziolkowski, Carla Bann, Marissa Trotta, Jamie E. Newman, Michele C. Walsh, Rosemary D. Higgins, Tanya E. Cahill, Andrea F. Duncan, Deanne E. Wilson-Costello, Myriam Peralta-Carcelén, Hope E. Arnold, Ricardo A. Mosquera, Roy J. Heyne, Janell Fuller, Elisabeth C. McGowan, Brenna Cavanaugh, Heidi M. Harmon, Nathalie L. Maitre, Mary Lauren Neel, Krisa P. Van Meurs, Laurie A. Richards, Howard W. Kilbride, Abbey C. Hines, Girija Natarajan, Andrea Trembath, Kristen Benninger, Kalpashri Kesavan, William Malcolm, Dinorah Zanger, Ann Marie Reynolds, Martha Carlson, Abhik Das, Namasivayam Ambalavanan, Fred J. Biasini, Waldemar A. Carlo, Monica V. Collins, Shirley S. Cosby, Kristy A. Domnanovich, Tara E. McNair, Vivien A. Phillips, Sally Whitley, Sheree York Chapman, Barbara Alksninis, Robert T. Burke, Melinda Caskey, Angelita M. Hensman, Laurie Hoffman, Katharine Johnson, Martin Keszler, Mary Lenore Keszler, Andrea M. Knoll, Abbot R. Laptook, Theresa M. Leach, Emilee Little, Julia Mayne, Lucille St. Pierre, Bonnie E. Stephens, Elisa Vieira, Praveen Chandrasekharan, Kelly R. Coleman, Jennifer Donato, Stephanie Guilford, Michelle Hartley-McAndrew, Satyan Lakshminrusimha, Emily Li, Michael G. Sacilowski, Ashley Williams, Karen Wynn, William Zorn, Monika Bhola, Anna Maria Hibbs, Nancy S. Newman, Allison H. Payne, Elizabeth Roth, Bonnie S. Siner, Gulgun Yalcinkaya, Barbara D. Alexander, Traci Beiersdorfer, Juanita Dudley, Teresa L. Gratton, Cathy Grisby, Devan Hayes, Lisa Henkes, Lenora Jackson, Jennifer Jennings, Kristin Kirker, Kate Meister, Brenda B. Poindexter, Courtney K. Robinson, David G. Russell, Kurt Schibler, Sara Stacey, Stacey Tepe, Julia Thompson, Sandra Wuertz, Kimberly Yolton, Richard A. Polin, Luc P. Brion, Lijun Chen, Maria Magdalena Leon, Frances Eubanks, Alicia Guzman, Elizabeth T. Heyne, Lizette E. Lee, Natalia Lopez, E. Rebecca McDougald, Lara Pavageau, Anna E. Puentez, Pollieanna Sepulveda, Kristine Tolentino-Plata, Catherine Twell Boatman, Diana M. Vasil, Azucena Vera, Jillian Waterbury, Myra H. Wyckoff, Patricia L. Ashley, C. Michael Cotten, Kimberley A. Fisher, Ronald N. Goldberg, Ricki F. Goldstein, Kathryn E. Gustafson, Deesha Mago-Shah, Joanne Probst, Caitlin Stone, Mollie Warren, Ira Adams‐Chapman, Diane I. Bottcher, David P. Carlton, Sheena L. Carter, Lynn C. Comerford, Ellen C. Hale, Salathiel Kendrick-Allwood, Judith Laursen, Yvonne Loggins, Colleen Mackie, Maureen Mulligan LaRossa, Ravi M. Patel, Amy E. Sanders, Elizabeth Sewell, Gloria V. Smikle, Barbara J. Stoll, Nora I. Alaniz, Julie Arldt-McAlister, Fatima Boricha, Katrina Burson, Allison G. Dempsey, Elizabeth Eason, Carmen Garcia, Donna J. Hall, Janice John, Kathleen A. Kennedy, Amir Khan, Karen Martin, Sara C. Martin, Georgia E. McDavid, Shannon L. McKee, Patti L. Pierce Tate, Tina Reddy, Kimberly Rennie, Shawna Rodgers, Matthew A. Rysavy, Debasree Sana Boral, Daniel K. Sperry, Emily K. Stephens, Jon E. Tyson, Sharon L. Wright, Susan Gunn, Dianne E. Herron, Jeffery Joyce, Carolyn Lytle, L.A. Papile, Lucy Smiley, Gregory M. Sokol, Leslie Dawn Wilson, Edward F. Bell, Jane E. Brumbaugh, Diane L. Eastman, Claire A. Goeke, Karen Johnson, Mendi L. Schmelzel, Jacky R. Walker, John A. Widness, Dan L. Ellsbury, Tracy L. Tud, Cheri Gauldin, Anne Holmes, Kathy Johnson, Eugenia K. Pallotto, Allison Scott, William E. Truog, Nancy Batterson, Stephanie Burkhardt, Helen Carey, Michelle Chao, Erna Clark, Erin Fearns, Christine A. Fortney, Aubry Fowler, Jennifer L. Grothause, Julie Gutentag, Cole Hague, Sudarshan R. Jadcherla, Sarah A. Keim, Katelyn Levengood, Patricia Luzader, Nathalie L. Maitre, Jacqueline McCool, Leif D. Nelin, Mary Ann Nelin, Julia L. Newton, Courtney Park, Lindsay Pietruszewski, Jessica Purnell, Courtney Rice, Pablo J. Sánchez, Julie C. Shadd, Jonathan L. Slaughter, Kristi Small, Melanie Stein, Margaret Sullivan, Rox Ann Sullivan, Christopher J. Timan, Keith Owen Yeates, Lina Yossef‐Salameh, Andrew A. Bremer, Stephanie Wilson Archer, Soraya Abbasi, Judy Bernbaum, Laura M. Betancourt, Aasma S. Chaudhary, Eric C. Eichenwald, Danielle Foy, Karen Friedman, Marsha Gerdes, Hallam Hurt, Antoinette Mancini, Linda G. McWhorter, Barbara Schmidt, Jonathan Snyder, Stephen A. Bean, Kyle Binion, Melissa Bowman, Patricia R. Chess, Carol A. Cole, Caitlin Fallone, Osman Farooq, Ronnie Guillet, Cassandra A. Horihan, Julianne Hunn, Rosemary L. Jensen, Rachel Jones, Alison L. Kent, Deanna Maffett, Kimberly G. McKee, Joan Merzbach, Gary J. Myers, Constance Orme, Premini Sabaratnam, Ann Marie Scorsone, Holly I.M. Wadkins, Kelley Yost, Margaret M. Crawford, Jenna Gabrio, Marie G. Gantz, David LeBlond, Jeanette O’Donnell Auman, Lindsay Parlberg, Carolyn M. Petrie Huitema, Annie M. VonLehmden, Dennis Wallace, Kristin M. Zaterka-Baxter, Michelle Baack, Megan Broadbent, Chelsey Elenkiwich, Megan M. Henning, Lauritz R. Meyer, Sarah Van Muyden, M. Bethany Ball, Barbara Bentley, Valerie Y. Chock, Alexis S. Davis, Maria Elena DeAnda, Anne M. DeBattista, Beth Earhart, Elizabeth N. Reichert, Lynne C. Huffman, Casey E. Krueger, Ryan E. Lucash, Karen K. Morris, Melinda S. Proud, Barbara P. Recine, Lilia Rutkowska, Dharshi Sivakumar, David K. Stevenson, Heather Taylor, Hali E. Weiss, Teresa Chanlaw, Uday Devaskar, Meena Garg, Rachel Geller, Isabell B. Purdy, Janice Bernhardt, Carl Bose, Cynthia L. Clark, Matthew M. Laughon, Sneha Makhijani, Holly Martin, T. Michael O’Shea, Jennifer Talbert, Genny Taylor, Diane Warner, Janice Wereszczak, Conra Backstrom Lacy, Carol H. Hartenberger, Elizabeth Kuan, Mary Hanson, Sandra Sundquist Beauman, John Barks, Mary Christensen, Diane F. White, Stephanie A. Wiggins, Shawna Baker, Mariana Baserga, Jill Burnett, Susan Christensen, Laura Cole Bledsoe, Sean D. Cunningham, Jennifer O. Elmont, Becky Hall, Manndi C. Loertscher, Trisha Marchant, Earl Maxson, Kandace M. McGrath, Hena G. Mickelsen, Stephen D. Minton, Galina Morshedzadeh, Robin K. Ohls, Dilys M. Parry, Carrie A. Rau, Brixen A. Reich, Erika Reichman, Susan T. Schaefer, Mark J. Sheffield, Kelly Stout, Ashley L. Stuart, Kimberlee Weaver-Lewis, Kathryn D. Woodbury, Christine A. Gleason, Alexandra Bentley, Laura Edwards, Stephen D. Kicklighter, Ginger Rhodes-Ryan, Donna L. White, Prashant Agarwal, Monika Bajaj, Rebecca Bara, Kirsten Childs, Melissa February, Laura A. Goldston, Eunice Woldt, Mary E. Johnson, Janessa H. Manning, Bogdan Panaitescu, Beena G. Sood · 发表于：Archives of Pediatrics and Adolescent Medicine · 年份：2025 · DOI：10.1001/jamapediatrics.2025.4801 · 被引用次数：1 · 研究领域：Adrenal Hormones and Disorders、Stress Responses and Cortisol、Growth Hormone and Insulin-like Growth Factors

Importance: Bronchopulmonary dysplasia (BPD) is the most common in-hospital morbidity of prematurity, associated with significant long-term medical and neurodevelopmental sequelae and health resource utilization. The Neonatal Research Network (NRN) Hydrocortisone for BPD Trial evaluated the efficacy and safety of hydrocortisone to prevent BPD in high-risk very preterm infants; the impact of hydrocortisone on school-age outcomes in this trial cohort is previously unreported. Objective: To evaluate the impact of neonatal hydrocortisone treatment on early school-age functional motor, cognitive, academic, and pulmonary outcomes among children who participated in the Hydrocortisone for BPD Trial. Design, Setting, and Participants: This prospective long-term cohort study is a follow-up of a randomized clinical trial, the Hydrocortisone for BPD Trial, conducted at 19 centers of the Eunice Kennedy Shriver National Institute of Child Health and Human Development NRN. Participants, enrolled from August 2011 to February 2018, included intubated infants who had been born before 30 weeks' gestational age and had been mechanically ventilated for at least 7 days by postnatal day 14 to 28. They were eligible for a single, in-person, early school-age visit between corrected age 5 years 0 months and 7 years 11 months, conducted from September 2017 to July 2024. Data analysis was performed from July 2024 to September 2025. Intervention: Participants were randomized to a 10-day tapering course o...