Cardiovascular-kidney-metabolic syndrome stages and increased risk of all-cause and cause-specific mortality in UK Biobank

作者：Tingting Xu, Wei Jin, Ming Xu, Huiqin Li, Silu Chen, Hongsheng Ji, Junyi Xin, Yan Gao, Mulong Du · 发表于：American Journal of Preventive Cardiology · 年份：2025 · DOI：10.1016/j.ajpc.2025.101369 · 被引用次数：9 · 研究领域：Chronic Kidney Disease and Diabetes、Genetic Associations and Epidemiology、Diabetes Treatment and Management

Background: Cardiovascular-kidney-metabolic (CKM) syndrome poses a critical challenge for public health. However, its association with mortality risk remain inadequately characterized. Methods: 282,952 participants at baseline from the UK Biobank were monitored until November 12, 2021. Cox regression analyses evaluated the associations between CKM stages and the risk of all-cause and cause-specific mortality, including cardiovascular diseases (CVD), cancer, respiratory diseases, and digestive system diseases. Results: < 0.001). Conclusions: CKM stages are strongly associated with increased all-cause and cause-specific mortality. Early identification and intervention in CKM syndrome patients could be crucial for reducing premature mortality and improving public health.