Cardiovascular Events 1 Year After Respiratory Syncytial Virus Infection in Adults

作者：Anders Hviid, Thea Kølsen Fischer, Tor Biering‐Sørensen, Ingrid Bech Svalgaard · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.47618 · 被引用次数：7 · 研究领域：Respiratory viral infections research、Virology and Viral Diseases、SARS-CoV-2 and COVID-19 Research

Importance: Respiratory syncytial virus (RSV) infection has recently been recognized as common among adults, but data on the burden of cardiovascular disease (CVD) beyond the immediate acute phase are lacking. Objective: To estimate the 365-day absolute excess risk (risk difference) of composites of CVD and their individual components following laboratory-confirmed RSV infection in adults. Design, Setting, and Participants: This nationwide, registry-based, matched cohort study was conducted using Danish national health registries. Adults aged 45 years or older on January 1, 2019, with a laboratory-confirmed RSV infection between January 1, 2019, and December 31, 2024, were matched 1:1 on age, sex, and preexisting comorbid conditions to individuals without RSV infection. Similar matched cohorts were established for influenza infection, hip fracture, and urinary tract infection without sepsis as control groups. Exposure: Laboratory-confirmed RSV infection. Main Outcomes and Measures: The primary outcomes were major adverse cardiovascular events, comprising ischemic heart disease, stroke, and heart failure, and any cardiovascular event, comprising major adverse cardiovascular events together with arrhythmias, venous thromboembolism, and inflammatory heart disease. Matched individuals were followed up for up to 365 days after the index date. Absolute risk differences and 95% CIs were calculated at 30 and 365 days using cumulative incidences derived from the Aalen-Johansen estimat...