To explore the role of NABP2 in the immune microenvironment and metabolic pathway of liver cancer

作者：Ying Li, Yibing Han, Linyi Cheng, Jiayi Zhang, Ruolan Deng, Wen Qiu · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2025 · DOI：10.64898/2025.11.30.691448 · 研究领域：RNA Research and Splicing、RNA modifications and cancer、Cancer Immunotherapy and Biomarkers

Abstract Objective This study aims to explore the specific signaling pathways associated with the NABP2 gene and its potential molecular mechanisms influencing the progression of hepatocellular carcinoma (HCC), thereby identifying new therapeutic targets. Method We collected 50 normal and 374 tumor samples to investigate the differential expression of NABP2 in HCC. Variousgenomic, single-cell, and bioinformatic analyses, including gene microarray technology, were employed. Data processing and analysis were conducted using R language, focusing on the correlation between NABP2 expression, immune cell infiltration, drug sensitivity, and metabolic pathways. Results Our findings indicate that NABP2 plays a significant role in the development of HCC and the tumor immune microenvironment. Analyses such as GSVA and GSEA suggest that NABP2 may influence disease progression through involvement in key molecular signaling pathways, including DNA replication, mRNA splicing, and protein degradation. Furthermore, a notable correlation was observed between NABP2 and various metabolic pathways, as well as specific immune cell populations. Additionally, we identified potential chemotherapeutic agents for HCC based on drug sensitivity analysis. Conclusion These findings position NABP2 as a crucial biomarker for the progression and treatment of hepatocellular carcinoma, offering new insights into the pathogenesis and prognostic strategies for HCC in future research.