Oropouche virus: molecular virological characteristics and research progress of a neglected arbovirus

作者：Siyu Lin, Qian Wang, Cong Wang, Qi Liu · 发表于：Virology Journal · 年份：2025 · DOI：10.1186/s12985-025-03011-2 · 被引用次数：2 · 研究领域：Mosquito-borne diseases and control、Viral Infections and Vectors、Viral Infections and Outbreaks Research

Oropouche, second only to dengue, a public health concern in the Amazon Basin of South America, has caused multiple localized outbreaks since its initial identification in 1955. Recurrent epidemics have been reported across various regions, with over 500,000 confirmed cases reported to date [De lima STS, Hua X, Claro IM 31(4):838-42, 2025, Almeida JD, Tyrrell DA, 1(2):175-8, 1967]. From late 2023 to early 2024, the geographic range of OROV rapidly expanded, Epidemiological data indicate that the geographical spread of the virus has extended beyond endemic regions such as Bolivia, Brazil, Colombia, Peru, with imported cases successively reported in non-endemic areas including Italy and the United States, confirming its significant potential for cross-border transmission and global dissemination [Castilletti C, Mori A, Matucci A, 29(26), 2024, Benitez A J, Alvarez M, Perez L, 30(10): 2155-9, 2024]. Currently, there are notable gaps in surveillance networks and control capabilities for this pathogen, alongside a scarcity of fundamental research and countermeasures. Recent outbreaks have heightened concerns, as they not only threaten to overwhelm local healthcare systems but also raise alarms about the potential escalation to regional epidemics and even global public health emergencies. Through a comprehensive analysis of existing literature, this review systematically synthesizes current knowledge on the molecular characteristics, epidemiology, and available detection and treatm...