Cardiolipin’s multifaceted role in immune response: a focus on interacting proteins

作者：Zhuodong Chai, Yuqi Zhou, Sukria Hossain, K. Huynh, Sahelosadat Hajimirzaei, Yan Zhang, Jiaqian Qi, Guoying Zhang, Zhenyu Li, Yinan Wei · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1680326 · 被引用次数：15 · 研究领域：Mitochondrial Function and Pathology、interferon and immune responses、Viral Infections and Immunology Research

Cardiolipin is a unique and essential phospholipid that plays a pivotal role in cellular function. In eukaryotic cells, it is predominantly localized within the mitochondrial membranes, with the highest concentration in the inner mitochondrial membrane (IMM). Recent studies have highlighted the multifaceted role of cardiolipin in immune regulation. This review aims to provide a comprehensive overview of specific proteins that directly interact with cardiolipin and to elucidate how these interactions underlie its diverse and critical functions in innate immunity. In addition, we discuss the involvement of cardiolipin in various pathological conditions in which its protein interactions contribute to immune dysregulation.