PTPN22 Dephosphorylates CBL to Inhibit PD-L1 Ubiquitination and Drive Immunosuppression in Renal Cell Carcinoma

作者：Tong Jin, Jiahui Ma, Luping Wang, Xinbo Liu, Mengting Wu, Binqi Wang, Chan Gao, Siqi Zhu, Ruikai Zhang, Fanwei Xia, Jingkui Tian, Wei‐Guo Zhu, Juan Jin, Qiang He · 发表于：International Journal of Biological Sciences · 年份：2025 · DOI：10.7150/ijbs.122418 · 被引用次数：2 · 研究领域：Protein Tyrosine Phosphatases、Diabetes and associated disorders、Curcumin's Biomedical Applications

experiments demonstrated that combining curcumin with immune checkpoint inhibition (ICIs) further promotes T cell activation, inhibits Tregs infiltration, and enhances ICIs efficacy against tumor growth. Therefore, PTPN22 represents a therapeutic target for improving T cell exhaustion in RCC and enhance ICIs efficacy through CBL-mediated ubiquitination and degradation of PD-L1.