Nanoparticle retention enables non-invasive detection of metastases by magnetic particle imaging in murine breast cancer models

作者：Preethi Korangath, Hayden Carlton, Toby Sanders, Olivia C. Sehl, Suqi Ke, Abdul Rahman Mohtasebzadeh, Lyndsey Werhane, Cordula Grüttner, Chen Hu, Kathleen Gabrielson, Patrick Goodwill, Robert Ivkov · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.122259 · 被引用次数：2 · 研究领域：Characterization and Applications of Magnetic Nanoparticles、Geomagnetism and Paleomagnetism Studies、Nanoparticle-Based Drug Delivery

MPI using Pegylated Synomag® nanoparticles can successfully detect primary tumors and micrometastases away from large organs of the reticuloendothelial system. Nanoparticles were found in the tumor microenvironment, associated with stromal and immune cells, especially macrophages. This provides evidence to use MPI for noninvasive detection of highly inflammatory tumors and metastasis, as well as exploring their potential for other inflammatory diseases.