ROS-Responsive Double-Layer Microneedles Enable Sequential Antibacterial and Immunomodulatory Therapy for Infected Wound Healing

作者：Huifang Zhang, Zhongke Wang, Yujing Zhu, Ting Huang, Ziliang Xiu, Haozhe Huang, H.Y. Li, Jing Xie, Haixia Huang, Min Liu, Libo Sun, Yuyan Lan, Ling Guo · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.122865 · 被引用次数：12 · 研究领域：Wound Healing and Treatments、Advancements in Transdermal Drug Delivery、Planarian Biology and Electrostimulation

This study proposes an innovative therapeutic strategy that combines dual-drug delivery, oxidative microenvironment regulation, and immune modulation to promote the healing of chronic infected wounds. The MN@DOX+RES microneedles system demonstrates great potential in overcoming clinical challenges associated with infection, inflammation, and the limitations of conventional therapeutic approaches.