Clinical efficacy of ultrasound-guided needle knife therapy for carpal tunnel syndrome: A meta-analysis of randomized controlled trials

作者：Fang Tang, Shibao Lu, Jiatao Zhang, Pincao Gao, Qiaoxia Zhang, Xiang Li · 发表于：Medicine · 年份：2025 · DOI：10.1097/md.0000000000044158 · 被引用次数：3 · 研究领域：Peripheral Nerve Disorders、Orthopedic Surgery and Rehabilitation、Tendon Structure and Treatment

BACKGROUND: Ultrasound-guided needle-knife therapy has emerged as a widely adopted and clinically effective intervention for carpal tunnel syndrome (CTS), demonstrating significant therapeutic outcomes in clinical practice. However, there is currently a notable lack of systematic reviews and meta-analyses evaluating the therapeutic efficacy of ultrasound-guided needle-knife therapy in the management of CTS. Systematic review and meta-analysis to assess the effectiveness of ultrasound-guided needle-knife therapy in improving CTS symptoms, wrist function, nerve conduction, ultrasonic detection index, and clinical cure rate. METHODS: A PICO (Population [study participants], Intervention [exposure or treatment], Comparison [control intervention], and Outcome [key study outcomes]) search strategy was used to identify randomized controlled trials applying ultrasound-guided needle-knife therapy on patients with CTS. Methodology quality and risk of bias were assessed by the Cochrane Collaboration. Outcomes assessed were pain intensity, wrist function, nerve conduction, ultrasonic detection index, clinical effective rate, and clinical cure rate. RESULTS: Seventeen studies involving 996 patients were finally included. Test for overall effect using a random effects model showed that ultrasound-guided needle-knife therapy significant improving pain intensity (Visual Analogue Scale) (mean difference [MD] = 0.84, 95% confidence interval [CI] -1.13 to -0.55, P < .00001, I2 = 85%), wrist fun...