Estimation of General Practitioner Visits, Hospitalizations and Deaths Attributable to Respiratory Syncytial Virus and Influenza Virus, and Costs Associated With Hospitalizations, in Older Adults in France From 2010 to 2020

作者：Charles Nuttens, Vanessa Barbet, Clélia Bignon-Favary, Emilie Lambourg, S. Fiévez, E. Blanc, Mathias Vacheret, Hervé Liliu, Philippe Vanhems, Jean‐Sébastien Casalegno, Laurence Watier, Paul Loubet, Caihua Liang, Elizabeth Begier, Magali Lemaître · 发表于：Open Forum Infectious Diseases · 年份：2025 · DOI：10.1093/ofid/ofaf735 · 被引用次数：4 · 研究领域：Respiratory viral infections research、Influenza Virus Research Studies、Viral Infections and Immunology Research

Background: Respiratory syncytial virus (RSV) and influenza virus are leading causes of respiratory infections, causing substantial numbers of hospitalizations and deaths, particularly among vulnerable groups such as infants and older adults. While the burden of influenza virus infection is well-documented, the burden of RSV infection in the adult population is often underestimated due to diagnostic challenges and infrequent standard-of-care testing. This study aimed to estimate the incidence of general practitioner (GP) visits, hospitalizations, and deaths attributable to RSV and influenza virus infections in French adults aged ≥50 years, with a focus on ≥65 years, using a time-series model-based approach. In addition, costs associated with hospitalizations were calculated. Methods: Cyclic Poisson regression models and weekly data from French medical administrative databases and electronic medical records over ten epidemic seasons (2010-2020) were used to estimate incidences for RSV and influenza. The results were stratified by age group, diagnosis causes (respiratory and cardiorespiratory) and diagnosis type (primary and secondary). Average costs per hospitalization were calculated and multiplied by the number of hospitalizations estimated. Results: Among adults aged ≥65 years, we estimated RSV infection was responsible for 647 619 GP visits 24 319 hospitalizations, and 878 deaths per year. Incidence rates for GP visits for RSV were twice as large as for influenza; hospital...