Sequential α/β-C–H Functionalization of Monosubstituted Aliphatic Alkenes

作者：Yini Wang, Bing Xie, Chengxing Peng, Xiaoli Li, Xi Lu, Chao Chen, Guofu Zhong, Jian Zhang · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c04175 · 被引用次数：2 · 研究领域：Catalytic C–H Functionalization Methods、Radical Photochemical Reactions、Cyclopropane Reaction Mechanisms

Monosubstituted alkenes are widely utilized in organic synthesis. Although remarkable progress has been made in chelation-assisted alkenyl C-H functionalization, monosubstituted aliphatic alkene remains a challenging target due to reactivity and selectivity issues. Herein, we report on the first sequential α/β-C-H functionalization of monosubstituted aliphatic alkenes derived from bishomoallyl amines. This protocol showed wide functionality tolerance and afforded C-H alkenylation and allylation as well as alkynylation products with excellent regio- and stereoselectivity.