Effects of combined nutritional supplementation and exercise on proxy measures of muscle mass, strength, and function in older adults with sarcopenia: a 12-week multicentre RCT

作者：Jianqin Sun, Mei He, Min Chen, Yanqiu Chen, Wuke Yuan, Fangfang Song, Lei Ren, Honghua Shen, Jurong Zhang, Xiuhua Shen, Liwei Liu, Xiaochun Wu, Chen Wang, Jie-wen Lyu, Lei Xu, Zhang Yin, Yan Chen, Hao Zhang, Fei Xiao, Xiaoli Wang, Bo Zhai, Jinrong Li, Jie Chen · 发表于：Nutrition Journal · 年份：2025 · DOI：10.1186/s12937-025-01244-z · 被引用次数：6 · 研究领域：Nutrition and Health in Aging、Balance, Gait, and Falls Prevention、Body Composition Measurement Techniques

BACKGROUND: Although nutritional supplementation and exercise have shown independent efficacy in managing sarcopenia, data supporting their combined implementation in real-world clinical settings remain limited. METHODS: This 12-week multicenter randomized controlled trial enrolled 110 older adults (≥ 65 years) with sarcopenia or possible sarcopenia. Participants were randomly allocated (1:1) to either the intervention group (n = 55) or control group (n = 55). In addition to their habitual diets, the intervention group received daily muscle-targeted oral nutritional supplementation (MT-ONS, 2 × 10 g sachets/day: containing 8.4 g protein, 0.5 g calcium β-hydroxy-β-methylbutyrate, 200 IU D3 per sachet) alongside a structured exercise programs featuring twice-weekly resistance training (20 min/session), alternate-day chair-based exercises (10 min/session), and home-based activity recommendations. Control group participants maintained their habitual dietary and physical activity patterns without intervention. All outcome measures were assessed at baseline and post-intervention. RESULTS: The intervention group showed modest increases in BIA-derived appendicular lean tissue (mean change + 0.60 kg, 95% CI 0.33 to 0.88), skeletal muscle index (+ 0.20 kg/m², 95% CI 0.11 to 0.29), and handgrip strength (+ 2.22 kg, 95% CI 1.35 to 3.09) compared with the control group. Improvements were also observed in walking speed, chair-stand performance, Short Physical Performance Battery scores, se...