Recent clinical advances in fibroblast activation protein targeted radioligand therapy for solid tumors

作者：Xiaolong Wu, Yu Wang, Yingchun Li, Wenli Hu · 发表于：Frontiers in Nuclear Medicine · 年份：2025 · DOI：10.3389/fnume.2025.1737443 · 被引用次数：11 · 研究领域：Peptidase Inhibition and Analysis、Connective tissue disorders research、Cardiac Fibrosis and Remodeling

Fibroblast activation protein (FAP) is a type II transmembrane serine protease predominantly expressed by cancer-associated fibroblasts (CAFs) in more than 90% of epithelial malignancies. The advent of FAP inhibitor (FAPI)-based positron emission tomography (PET) imaging has established FAP as a promising pan-tumor target for radioligand therapy (RLT). This review summarizes the current clinical landscape of FAP-targeted RLT in solid tumors, while also discussing existing challenges and future directions in this rapidly evolving field.