Euphebranone F, a new acetophenone derivative fromthe Euphorbia fischeriana

作者：Yang Yu, M. Li, Ning-wen Xu, Bai-Xiang Cai, Ju-Tao Wang · 发表于：Records of Natural Products · 年份：2025 · DOI：10.25135/rnp.2511.3720 · 研究领域：Bioactive Natural Diterpenoids Research、Phytochemistry and Bioactive Compounds、Biological Stains and Phytochemicals

Phytochemical investigation of the roots of Euphorbia fischeriana led to the isolation of a novel acetophenone derivative, named Euphebranone F (1), along with three known acetophenone analogs (2-4).The structure of the new compound, featuring a C-C linkage between the C-9 of the acetophenone unit and C-8 ′ of the phenylpropanoid moiety, was elucidated by extensive NMR and HRESIMS analysis, and its absolute configuration was determined by ECD calculations.Cytotoxic activity screening against human gastric cancer cell lines (MKN-45 and AGS) revealed that only compound 2 exhibited moderate antiproliferative activity against MKN-45 cells.