Interim analysis of PRO-MIND: Consistent quality of life in elderly patients with R/R DLBCL receiving tafasitamab and lenalidomide

作者：Pier Luigi Zinzani, Maria Christina Cox, Flaminia Bellisario, Andrea Bernardelli, Maurizio Musso, Guido Gini, Alice Di Rocco, Eliana Valentina Liardo, Enrico Derenzini, Elsa Pennese, Nicholas Battaglia, Mario Lapecorella, Antonio Pinto · 发表于：Blood · 年份：2025 · DOI：10.1182/blood-2025-7248 · 被引用次数：1 · 研究领域：Lymphoma Diagnosis and Treatment、Chronic Lymphocytic Leukemia Research、Protein Degradation and Inhibitors

Abstract Background: While there is increasing real-world (RW) evidence on the tafasitamab-lenalidomide (TL) combination in patients (pts) with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL), data regarding its impact on health-related quality of life (HRQoL) are still lacking. HRQoL is a crucial pt-reported outcome for evaluating the effects of a specific treatment in a RW setting, along with clinical effectiveness. We present HRQoL data from an interim analysis of the PRO-MIND study (NCT06299553) of TL in pts with R/R DLBCL in Italy. Methods: PRO-MIND is a noninterventional, multicenter, prospective observational cohort study conducted at 30 sites. It is enrolling adult pts with R/R DLBCL ineligible for autologous stem cell transplant (ASCT) who are receiving TL as a second, third, or fourth line of treatment, following standard clinical practices in Italy. HRQoL was measured with the EORTC QLQ-C30 and the high-grade lymphoma-specific EORTC QLQ-NHL-HG29. Questionnaires were administered during preplanned sequential study visits. Comparison of PRO-MIND HRQoL scores with an age-matched normative Italian population was conducted with Welch's t-test. Questionnaires were analyzed using mixed-model for repeated measures for longitudinal changes and by Cox regression analysis to verify the association between baseline scores and progression-free survival (PFS) and overall survival (OS). Results: At the cut-off date of January 31, 2025, 52 pts (27 males, 25 females) ...