Targeting neuroinflammation and PVNCRH neurons: dexmedetomidine liposomes for perioperative neurocognitive disorder with comorbid anxiety

作者：Jingjing Lv, Liang Yao, Ying Wang, Zihuan Xu, Chen Hu, Su-Fen Pu, Zhiheng Liu, Zhilai Yang, Jiqian Zhang, Xuesheng Liu · 发表于：Materials Today Bio · 年份：2025 · DOI：10.1016/j.mtbio.2025.102634 · 被引用次数：1 · 研究领域：Intensive Care Unit Cognitive Disorders、Anesthesia and Neurotoxicity Research、Neuroinflammation and Neurodegeneration Mechanisms

fiber photometry revealed that DEX significantly suppressed corticotropin-releasing hormone (CRH) neuron activity in the paraventricular nucleus (PVN), contributing to its anxiolytic effect. These findings highlight a promising translational nanotherapeutic strategy for the dual prevention of PND and anxiety by targeting molecular signaling pathways and neural circuits.