Prostate Cancer Risk and DNA Mismatch Repair Deficiency Among Lynch Syndrome Patients

作者：Linda Rodgers, Nick Kamkari, Melany Cruz, Andrew Gusev, Sara I. Justiniano, Chin‐Lee Wu, Daniel C. Chung, Keyan Salari · 发表于：European Urology Open Science · 年份：2025 · DOI：10.1016/j.euros.2025.11.006 · 被引用次数：1 · 研究领域：Genetic factors in colorectal cancer、Prostate Cancer Diagnosis and Treatment、Prostate Cancer Treatment and Research

Background and objective: Lynch syndrome (LS) increases the risk of gastrointestinal, endometrial, and other cancers. Recent data suggest that LS also increases the risk of prostate cancer (PC). Our study aims to characterize the incidence and the clinical and molecular features of PC in LS. Methods: Adult males with LS were identified from an institutional genetic testing registry. PC diagnoses were identified, and tumor tissue was assessed for DNA mismatch repair deficiency (dMMR) by immunohistochemistry. Key findings and limitations: < 0.001) than those without a family history. This study was limited by the number of cases at one institution. Conclusions and clinical implications: PV, and/or a family history of PC. Patient summary: In this study, we looked at the incidence and characteristics of prostate cancer that develops among individuals with Lynch syndrome. We found that individuals with Lynch syndrome have an elevated risk of developing prostate cancer, but this risk varied by Lynch syndrome gene and family history. This information will help guide targeted prostate cancer screening and management for individuals with Lynch syndrome.