Ultraviolet A1 phototherapy for improvement of hand function in scleroderma: a blinded prospective study

作者：Rachel Seifert, Christiaan H Noot, Vikram N. Sahni, Amber Jimenez, Laurel Gray, Zachary Hopkins, Tracy Frech, Christopher B. Hansen · 发表于：British Journal of Dermatology · 年份：2025 · DOI：10.1093/bjd/ljaf488 · 被引用次数：1 · 研究领域：Systemic Sclerosis and Related Diseases、Dermatologic Treatments and Research、Multiple Sclerosis Research Studies

Effective tools for improving sclerotic hand changes in patients with systemic sclerosis are lacking; thus, we conducted a single-blind prospective randomized clinical trial investigating the impact of UVA1 phototherapy on scleroderma of the hands. Seven patients were unilaterally treated, and we found no evidence of significant change in Hand Mobility in Scleroderma (HAMIS) scores after 30 treatments. However, patients did report significant health-related outcome changes in the emotional, symptomatic and functional domains of Skindex-16 [β = –34.1 (95% CI –47.0 to –21.3), –26.3 (–38.1 to –14.4) and –13.1 (–20.9 to –5.41), respectively].