Traditional Uses, Phytochemistry, Pharmacology, and Toxicology of Belamcanda chinensis: A Review

作者：Tieqiang Zong, Mingxia Li, Zhengyu Hu, Long Hao Jin, Yanan Liu, Yuanqi Duan, Jinfeng Sun, Wei Zhou, Gao Li · 发表于：Plants · 年份：2025 · DOI：10.3390/plants14233688 · 被引用次数：2 · 研究领域：Bioactive natural compounds、Traditional and Medicinal Uses of Annonaceae、Phytochemistry and Biological Activities

The Belamcanda chinensis (L.) Redouté is a perennial herb belong to the genus Belamcanda, primarily found in China, but with additional distribution in North Korea, South Korea, Japan, and India. The rhizomes of B. chinensis have a long history of use as a traditional herbal medicine in China, one that is recognized for its effects in clearing heat, in detoxifying and eliminating phlegm, and in soothing the throat. In this review, we conducted a comprehensive search across several databases, both Chinese and international, using the primary keyword Belamcanda chinensis paired with a relevant research area (e.g., chemical composition, pharmacology). The databases included Sci-Finder, ScienceDirect, PubMed, China National Knowledge Infrastructure, Wiley, Springer Baidu Scholar and Research Gate, as well as domestic materia medica. We illustrated the chemical structures using ChemBioDraw Ultra 22.0 software. There are more than 10 proprietary Chinese medicines already on the market that consist of or originate from B. chinensis. More than 200 natural products have been isolated and identified from B. chinensis, including iridal-type triterpenoids, flavonoids, phenolics, quinones, sesquiterpenes, and polysaccharides. Modern pharmacological studies indicate that both crude extracts and monomeric compounds exhibit anti-inflammatory, anti-tumor, antioxidant, neuroprotective and anti-diabetic activities, with potential regulatory pathways. Additionally, B. chinensis demonstrates toxi...