An aggregation-induced emission-active theranostic agent for selectively detecting and intervening pathological Tau protein

作者：Jixue Yang, Youwen Deng, Shukui Qin, Ziting Chen, Yuting Lu, Shunli Ji, Taijun Hang, Min Song · 发表于：Journal of Materials Chemistry B · 年份：2025 · DOI：10.1039/d5tb01783a · 被引用次数：1 · 研究领域：Alzheimer's disease research and treatments、Supramolecular Self-Assembly in Materials、Luminescence and Fluorescent Materials

, and the staining consequence is almost consistent with that of ThT. On the other hand, as a modulator, TPE-P9 can potently protect neurons from cytotoxic Tau-induced apoptosis both by inhibiting aberrant post-translational modification-induced Tau self-assembly and by blocking the produced pathological Tau propagation, enhancing cell viability by 35.4%. These findings offer valuable insights for the development of innovative image-guided therapeutic strategies for targeted tauopathies treatment.