Application of radiotherapy-preexcited gambogic acid dual targeting nanoparticles in colorectal cancer

作者：Liuqi Sang, Qun Zhang, Zixin Liang, Xinyi Xu, Xueying Bai, Ning Wang, Xingzhi Han, Li Li, Jing Hu, Xiaoping Qian · 发表于：RSC Advances · 年份：2025 · DOI：10.1039/d5ra02815a · 研究领域：Seaweed-derived Bioactive Compounds、Natural Compound Pharmacology Studies、Bioactive Compounds and Antitumor Agents

experimental results demonstrate that FPG has excellent binding capability to tumor cells and endothelial cells. The radiation-induced differential expression of P-selectin further enhances drug-targeted delivery. FPG combined with radiotherapy exhibited significant advantages in inhibiting tumor growth, inducing apoptosis, reducing tumor volume, modulating the immune microenvironment, and promoting cell phagocytosis. This targeted delivery system holds great potential for improving tumor treatment efficacy and reducing side effects in future cancer therapies.