Vitamin D Levels During Pregnancy and Dental Caries in Offspring

作者：Nuo Xu, Zexin Chen, Boya Wang, Yiwen Qiu, Xialidan Alifu, Haibo Zhou, Haoyue Cheng, Ye Huang, Libi Zhang, Hui Liu, Lina Yu, Danqing Chen, Yunxian Yu · 发表于：JAMA Network Open · 年份：2025 · DOI：10.1001/jamanetworkopen.2025.46166 · 被引用次数：2 · 研究领域：Vitamin D Research Studies、Oral microbiology and periodontitis research、Dental Health and Care Utilization

Importance: Maternal vitamin D level during pregnancy has been repeatedly reported to be associated with early childhood caries (ECCs) in offspring, yet the conclusions remain inconsistent. Objective: To evaluate the association between maternal vitamin D status in different trimesters during pregnancy and offspring dental caries. Design, Setting, and Participants: This prospective cohort study was based on the Zhoushan Pregnant Women Cohort, which enrolled pregnant women between August 2011 to May 2021, and followed up on their offspring until November 2022, at Zhoushan Maternal and Child Health Hospital in Zhoushan, Zhejiang Province, China. Data were analyzed from October 2024 to April 2025. Exposures: Maternal plasma 25-hydroxyvitamin D (25[OH]D) levels measured in the first, second, and third trimesters and vitamin D deficiency (VDD). Main Outcomes and Measures: The primary outcome was offspring ECCs. Secondary outcomes included the decayed, missing, or filled teeth (dmft, with lowercase term denoting primary, instead of permanent, dentition) index and caries rate (the ratio of dmft to number of erupted teeth). Results: The cohort included 4109 mother-offspring pairs (maternal median [IQR] age, 29.0 [27.0-32.0] years; offspring gestational age at birth, 39.0 [38.0-40.0] weeks; 2121 males [51.6%]), of whom 960 children had ECCs and 3149 did not. Higher maternal 25(OH)D levels were associated with reduced odds of ECCs in offspring (first trimester odds ratio [OR], 0.98 [95...