Metal- and photocatalyst-free C3–H functionalization of quinoxalin-2(1 H )-ones enabled by electron donor–acceptor complex photoactivation

作者：Chen An, Yuexin Du, Xinchang Wang, Yang Xu, Xiaoyang Yao, Hong Yu, Wanmei Li · 发表于：Organic & Biomolecular Chemistry · 年份：2025 · DOI：10.1039/d5ob01618e · 被引用次数：2 · 研究领域：Radical Photochemical Reactions、Catalytic C–H Functionalization Methods、Synthesis and Biological Evaluation

-toluenesulfonic acid. The reaction proceeds under mild conditions (violet LED irradiation, air atmosphere) and exhibits broad substrate scope, accommodating a wide range of quinoxalinones and (hetero)aryl/alkyl boronic acids to deliver the products in moderate to excellent yields. Mechanistic studies confirm the involvement of a radical pathway and the critical role of the EDA complex. The practicality of this method is demonstrated by its scalability and successful late-stage functionalization of drug-like molecules.