Dynamic Associations between Ambient PM 2.5 and Its Components and Transitions of Clinical Pregnancy and Adverse Reproductive Outcomes among Participants Treated with ART

作者：Zhonghua Ai, Yajun Dong, X. F. Li, Zilong Zhang, Zitong Zhuang, Manting Rao, Yan Jia, Hualiang Lin · 发表于：Environment & Health · 年份：2025 · DOI：10.1021/envhealth.5c00442 · 被引用次数：2 · 研究领域：Air Quality and Health Impacts、Atmospheric chemistry and aerosols、Climate Change and Health Impacts

High Resolution Image Download MS PowerPoint Slide Evidence remains unknown regarding the associations between PM 2.5 and its components exposure and dynamic progression of different assisted reproductive outcomes in participants undergoing fresh embryo transfer. We included infertile participants at a major assisted reproductive specialist hospital in Chengdu, China, between 2019 and 2022. We conducted multistate modeling and the quantile g-computation approach to explore the association between PM 2.5 and its components [black carbon (BC), organic matter (OM), sulfate (SO 4 2– ), nitrate (NO 3 – ), ammonium (NH 4 + ) ] and the mixtures with six transitions (from infertility status to clinical pregnancy, from clinical pregnancy to preterm birth (PTB), from clinical pregnancy to miscarriage, from clinical pregnancy to pregnancy complications, from pregnancy complications to PTB, and from pregnancy complications to miscarriage). Mediation analyses were further conducted to explore potential mediating role of reproductive parameters in the associations. Among 11,447 infertile participants with in vitro fertilization, we observed that exposure to higher concentrations of PM 2.5 and its components and the mixtures in the 3 months prior to embryo transfer was associated with the progression of the reproductive outcomes, only BC and OM are associated with miscarriage. For example, for each interquartile range increase in OM, the hazard ratios (HRs) were 0.956 [95% confidence interv...