Towards clinical magnetic particle imaging: safety measurements of medical implants in a human cadaver model

作者：Franz Wegner, Thomas Friedrich, Patrick N. Elfers, Florian Kleefeldt, Dominik Peter, Philipp Gruschwitz, Teresa Reichl, Johanna Günther, Thomas Kampf, Martin A. Rückert, Volker C. Behr, Thorsten M. Buzug, Roman Kloeckner, Jörg Barkhausen, Thorsten Alexander Bley, Patrick Vogel, Viktor Hartung · 发表于：Communications Engineering · 年份：2025 · DOI：10.1038/s44172-025-00561-9 · 被引用次数：2 · 研究领域：Characterization and Applications of Magnetic Nanoparticles、Electrical and Bioimpedance Tomography、Geomagnetism and Paleomagnetism Studies

Magnetic Particle Imaging (MPI) is a preclinical imaging modality with potential for future clinical usage. The radiation-free guidance of endovascular interventions with MPI is especially promising. Here, we present a safety study on the heating of metallic medical implants during MPI measurements under realistic conditions in an extracorporeally-perfused cadaver model. The measurements were conducted by fiberoptic thermometers and showed no detectable heating of the tested endovascular devices in the cadaver model. A temperature increase of no more than 0.11 K was observed on the surface of the investigated proximal femoral nail. The in vitro testing of orthopedic prostheses (knee and hip) revealed a slight heating effect of 0.45 K. The dependence of heating on the applied excitation frequency was measured. Overall, the tested repertoire of implants did not heat by a clinically-relevant amount in a human-sized MPI-scanner under realistic conditions, indicating their safe usage in future clinical applications.