Dystrophin deficiency stiffens skeletal muscle and impairs elasticity: an in vivo rheological examination

作者：Pavithran Devananthan, R. R. Craven, Kellie Joe, Gretel Major, Jiayi Chen, Natalia Kabaliuk, Angus Lindsay · 发表于：Journal of Applied Physiology · 年份：2025 · DOI：10.1152/japplphysiol.00492.2025 · 被引用次数：2 · 研究领域：Muscle Physiology and Disorders、Cardiomyopathy and Myosin Studies、Nutrition and Health in Aging

Myomechanical profiling was developed using cyclic rheometry to assess the in vivo viscoelastic properties of mouse skeletal muscle-the in vivo environment is maintained alongside high measurement sensitivity and spatial resolution, and the ability to apply deformation transverse to fiber orientation. Myomechanical profiling was trialed in dystrophin-positive and dystrophin-negative (model of Duchenne muscular dystrophy) skeletal muscle, and showed that the loss of the biomechanical protein dystrophin increased stiffness and impaired elasticity after compressive and rotational shear deformation.