An investigation on Alzheimer’s disease with obstructive sleep apnea: alterations of cognitive function, roles of cyclin-dependent kinase 5 and changes of brain structure

作者：Dongmei Luo, Tenghong Lian, Ning Wei, Peng Guo, Mingyue He, Yanan Zhang, Yue Huang, Gaifen Liu, Jinghui Li, Jing Li, Jing Qi, Huiying Guan, Wenjing Zhang, Wenjing Zhang, Weijia Zhang, Weijia Zhang, Zijing Zheng, Hao Yue, Zhan Liu, Fan Zhang, Yao Meng, Wei Zhang, Wei Zhang · 发表于：Frontiers in Aging Neuroscience · 年份：2025 · DOI：10.3389/fnagi.2025.1552535 · 被引用次数：1 · 研究领域：Obstructive Sleep Apnea Research、Sleep and Wakefulness Research、Sleep and related disorders

Aims To investigate alterations of cognitive function, roles of cyclin-dependent kinase 5 (CDK5) and changes of brain structure in Alzheimer’s disease (AD) with obstructive sleep apnea (OSA). Methods Total 94 AD with OSA (AD-OSA) patients were divided into 49 cases of AD with mild OSA (AD-OSA-M) and 45 cases of AD with moderate and severe OSA (AD-OSA-MS). Demographic characteristics, cognitive function, the levels of AD neuropathological proteins, CDK5 and synaptic proteins in cerebrospinal fluid (CSF), and brain volume by magnetic resonance imaging were compared between the two groups. The correlations among OSA and the above variables were analyzed. Results Compared with AD-OSA-M group, AD-OSA-MS group had a higher body mass index, lower scores of AVLT N7 and SCWT-C, longer SCWT-C time, higher levels of phosphorylated tau (P-tau) 396 and synaptophysin, lower CDK5 level and smaller volumes of brain gray and white matters in parts of frontal, parietal, temporal and occipital lobes. In AD-OSA patients, the decreased CDK5 level was correlated with the elevated levels of P-tau 396 and synaptophysin in CSF. In AD-OSA-MS group, reductions of gray matter and white matter volumes associated with OSA exacerbation was correlated with memory and executive function impairments. The p -values of above results were <0.05. Conclusion In AD-OSA, OSA exacerbation is associated with memory impairment and executive dysfunction, P-tau 396 elevation and CDK5 decline in CSF, synaptic disru...