Association between the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and 28-day mortality in neurocritical care patients: a retrospective cohort study based on the MIMIC-IV database

作者：Yajun Zou, Xia Yu, Li Hu, Teng Long, Zhipeng Wang, Min Shao, Yuxin Chen, Jianlin Zhang · 发表于：European journal of medical research · 年份：2025 · DOI：10.1186/s40001-025-03437-y · 被引用次数：5 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Platelet Disorders and Treatments、Sepsis Diagnosis and Treatment

BACKGROUND: In recent years, reliable prognostic markers are increasingly important in neurocritical care. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score, a composite biomarker reflecting systemic immune-nutritional status, has shown promise as a predictor. This study aims to evaluate the prognostic value of the HALP score for predicting 28-day mortality in neurocritical care unit (NCCU) patients. MATERIALS AND METHODS: We conducted a retrospective cohort study by identifying neurocritical care patients from the MIMIC-IV database. The association between the HALP score and 28-day mortality was primarily assessed using multivariable Cox proportional hazards regression. Multiple analytical approaches were employed to comprehensively examine this relationship, including restricted cubic spline (RCS) regression to evaluate nonlinearity and Kaplan-Meier survival analysis. A risk prediction nomogram was developed based on a Cox regression model. The model's discriminative performance at 28 days was evaluated using receiver operating characteristic (ROC) curve analysis, with the area under the curve (AUC) quantified using logistic regression. RESULT: Finally, 858 patients in the MIMIC database were analyzed, with 28-day ICU and in-hospital mortality rates of 21.0% and 20.4%, respectively. In the fully adjusted Cox model for ICU mortality, notably, the continuous HALP score was not independently predictive (HR = 0.99, 95% CI 0.98-1.00, p = 0.13). However, when analyze...