Health impact of alcohol use in the USA: a protocol of a systematic review and modelling study

作者：Kevin D. Shield, Katherine M. Keyes, Priscilla Martínez, Adam J. Milam, Jürgen Rehm, Sinead George, Timothy S. Naimi · 发表于：BMJ Open · 年份：2025 · DOI：10.1136/bmjopen-2024-093389 · 被引用次数：2 · 研究领域：Substance Abuse Treatment and Outcomes、Alcohol Consumption and Health Effects、Alcoholism and Thiamine Deficiency

INTRODUCTION: Alcohol is consumed by an estimated 137.4 million people in the USA 12 years of age and older and, as a result, is estimated to have caused about 140 thousand deaths among people 20 to 64 years of age each year from 2015 up to and including 2019. METHODS: . A multi-method approach will be utilised to formulate conclusions on (i) weekly (ie, average) thresholds to minimise long-term and short-term risks of morbidity and mortality, (ii) daily thresholds to minimise the short-term risk of injury or acute illness due to per occasion drinking, (iii) alcohol use among vulnerable populations (eg, pregnant women) and (iv) situations and circumstances that are hazardous for alcohol use. To inform expert decisions, this project will also include a systematic review of existing low-risk drinking guidelines, a systematic review of meta-analyses which examine alcohol's impact on key attributable disease and mortality outcomes, and of estimates of the lifetime absolute risk of alcohol-attributable mortality and morbidity based on a person's sex and average level of alcohol use. The systematic reviews were designed in accordance with the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P). The preliminary conclusions produced as a result of this project will undergo public consultation, and data from these consultations will be qualitatively analysed. The results of the public consultations will be used to further revise and refine the projec...