Recommendations from the WHO guideline for the prevention, diagnosis, and treatment of infertility

作者：Gitau Mburu, Nancy Santesso, Romina Brignardello‐Petersen, Richard H. Kennedy, Cindy Farquhar, Jacky Boivin, Guido Pennings, Linda C. Giudice, Robert W. Rebar, Luca Gianaroli, Lan N. Vuong, Sandro C. Esteves, Christopher J. De Jonge, Allan Pacey, Willem Ombelet, Tansu Küçük, Barbara Collura, Klaudija Kordic, Paula Amato, Thabo Matsaseng, James Kiarie · 发表于：Fertility and Sterility · 年份：2025 · DOI：10.1016/j.fertnstert.2025.11.014 · 被引用次数：12 · 研究领域：Reproductive Health and Technologies、Ovarian function and disorders、Reproductive Biology and Fertility

BACKGROUND: The field of sexual and reproductive health care, including family planning has progressed in the last several decades. Significant progress has also been made in the field of medically assisted reproduction. Globally one in six people experience infertility in their lifetime. However, many countries do not include the prevention, diagnosis, and treatment of infertility in health policies, financing and services, and many do not have national clinical guidelines for the prevention, diagnosis and treatment of infertility. OBJECTIVE: To determine what interventions are recommended for prevention, diagnosis and treatment of infertility among individuals and couples. DESIGN, SETTING: The guideline was developed according to the WHO handbook for guideline development. A Guideline Development Group (GDG) was assembled and included a multidisciplinary and regionally diverse set of clinicians, policymakers, researchers, implementers and representatives of patient groups (n=30). The GDG prioritised key recommendation questions to address in the guideline. New systematic reviews were conducted, or existing reviews updated, to inform the recommendations. The GRADE approach was used to assess the certainty of the evidence and to guide the formulation of recommendations. MAIN OUTCOME MEASURES: The GDG interpreted evidence and made judgments about the balance between benefits and harms (including patients' values) as well as costs, feasibility, acceptability, and equity. The re...