Explainable multi-modal machine learning for predicting occult pulmonary metastases in differentiated thyroid cancer: a SHAP-based approach prior to radioactive iodine scans

作者：Youwu Su, Yukun Cai, Shui Jin, Xuemei Ye, Jaesik Jeong, Ye Yuan, Heqing Yi · 发表于：Frontiers in Medical Technology · 年份：2025 · DOI：10.3389/fmedt.2025.1685088 · 被引用次数：2 · 研究领域：Thyroid Cancer Diagnosis and Treatment、Explainable Artificial Intelligence (XAI)、Artificial Intelligence in Healthcare and Education

Background Patients with differentiated thyroid cancer (DTC) may have occult lung metastases before 131 iodine ( 131 I) treatment. Identifying occult lung metastases before 131 I treatment is of great clinical value for the correct staging of patients and the establishment of 131 I treatment plans. Our research is of great significance in establishing statistical models for clinical data using machine learning algorithms to study the prediction of lung metastasis before 131 I treatment. Methods Patients were selected from Zhejiang cancer hospital and data was from two groups of DTC patients treated with 131 I, where the experimental group consisted of 55 patients who showed no lung metastases on CT but tested positive on 131 I-whole body scan ( 131 I-WBS). The control group included 316 patients who tested negative for metastases across CT, ultrasound, and 131 I-WBS. Six machine learning algorithms such as Support Vector Machines (SVM), Decision Trees (DT), Random Forests (RF), Logistic Regression (LR), Extreme Gradient Boosting (XGBoost), and K-Nearest Neighbors (KNN) were employed to predict models and AUC, sensitivity, accuracy, precision, specificity, F1 Score were used to compare the performance between each models. Finally, the SHAP algorithm was used to explain the importance rank of the features. Results A total of 371 thyroid cancer patients were included in this study, 55 patients with occult lung metastasis and 316 patients in the control group. The data is divided...