Examining Self‐Reported Executive Function and Its Relationship to Patient‐Reported Outcomes and Disease‐Related Factors in Youth With Childhood‐Onset Lupus: A Cross‐Sectional Study

作者：Tala El Tal, Jida Jaffan, Justine Ledochowski, Sarah I. Mossad, Lawrence Ng, Asha Jeyanathan, Adrienne L. Davis, Linda T. Hiraki, Deborah M. Levy, Zahi Touma, Natoshia R. Cunningham, Ashley Danguecan, Andrea Knight · 发表于：ACR Open Rheumatology · 年份：2025 · DOI：10.1002/acr2.70102 · 被引用次数：2 · 研究领域：Systemic Lupus Erythematosus Research、Rheumatoid Arthritis Research and Therapies、Growth Hormone and Insulin-like Growth Factors

OBJECTIVE: Up to 60% of youth with childhood-onset systemic lupus erythematosus (cSLE) experience cognitive dysfunction, impacting their quality of life and medication adherence. This study explored self-reported executive function (EF) and its links to patient-reported outcomes and disease-related factors in cSLE. METHODS: This cross-sectional study compared patients aged 10 to 17 years with cSLE to age- and sex-matched controls. The Behavior Rating Inventory of Executive Function Self-Report Global Executive Composite (GEC) T score measured daily EF activities, whereas Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires assessed pain, sleep, fatigue, anxiety, and depression. Group differences in GEC and correlations with PROMIS scores were analyzed. For patients with cSLE, hierarchical regression evaluated GEC variance explained by income, PROMIS scores, and disease-related factors (activity, damage, and glucocorticoid use). RESULTS: We recruited 94 participants, including 52 patients with cSLE and 42 controls. The analysis revealed no group difference in GEC T scores. In the cSLE group, worse depression and sleep disturbance correlated with worse GEC T scores, whereas pain interference and fatigue correlated with GEC in both groups. The hierarchical regression model explained 30% (P = 0.003) of EF variability in cSLE. PROMIS measures accounted for 14% (P = 0.013) of EF variability when controlling for household income. Disease-related factors c...