Photodynamic therapy for extramammary paget’s disease: A retrospective analysis of 15 cases

作者：Feng Chen, Lingling Sun, Zeng Ruifang, Xiaohua Chen, LI Li-bo, Xiaojun Cai · 发表于：Photodiagnosis and Photodynamic Therapy · 年份：2025 · DOI：10.1016/j.pdpdt.2025.105301 · 被引用次数：4 · 研究领域：Cancer and Skin Lesions、Nonmelanoma Skin Cancer Studies、Hedgehog Signaling Pathway Studies

• This retrospective study evaluated photodynamic therapy (PDT) in 15 extramammary Paget’s disease (EMPD) patients, achieving 40 % complete and 46.7 % partial remission. • PDT was well-tolerated, with transient pain, mild erythema/edema, occasional local infection or scarring, and no functional impairment. • However, 4 of 6 complete responders relapsed 11–87 months later, underscoring suboptimal long-term control. • Lesion thickness, prior treatments, and photosensitizer choice (topical ALA vs systemic HpD) influenced outcomes; combination or repeat sessions improved response. • We conclude PDT is a safe, organ-sparing option for inoperable or recurrent EMPD, but larger prospective trials and combination strategies are needed to raise cure rates and reduce recurrence. Extramammary Paget's disease (EMPD) is a rare cutaneous malignancy. Photodynamic therapy (PDT) has shown promise as a treatment option for various skin cancers, including EMPD. This study aims to assess the clinical effectiveness of PDT in treating 15 cases of EMPD. A retrospective analysis was conducted on 15 patients diagnosed with EMPD in the Oncology Department of Southern Medical University Hospital of Integrated Traditional Chinese and Western Medicine from June 2014 to December 2024, all of whom received PDT as part of their treatment. According to the therapeutic regimens, patients were stratified into three cohorts: group A received systemic hematoporphyrin-derivative (HpD) PDT (with or without sequenti...