Clinical characteristics, management and outcomes of enterococcal infective endocarditis: an ancillary study from the ESC-EORP EURO-ENDO registry

作者：Mary Philip, Robinson Gravier Dumonceau, Rodolfo Citro, Bernard Cosyns, Erwan Donal, Paola Anna Erba, Frédérique Gouriet, Bernard Iung, William Kong, Patrizio Lancellotti, Aldo P. Maggioni, Julien Mancini, Bogdan A. Popescu, Bernard Prendergast, Antonia Sambola, Shantanu P. Sengupta, Ana Teresa Timóteo, Christophe Tribouilloy, Joost van Melle, Roch Giorgi, Gilbert Habib, EURO-ENDO Investigators, Roberto Ferrari, A Alonso, J. J. Bax, Carina Blomström‐Lundqvist, S. Gielen, Patrizio Lancellotti, A P Maggioni, N Maniadakis, Fausto J. Pinto, Frank Ruschitzka, L Tavazzi, P Vardas, F Weidinger, Uwe Zeymer, Alec Vahanian, Andrzej Budaj, Nikolaos Dagres, N Danchin, Victoria Delgado, Jonathan Emberson, Örjan Friberg, Chris P Gale, Gr. Heyndrickx, B Iung, Sherman A. James, A P Kappetein, A P Maggioni, N Maniadakis, K V Nagy, G Parati, A-S Petronio, Mikko Pietilä, E Prescott, Frank Ruschitzka, Frans Van de Werf, F Weidinger, Uwe Zeymer, Gilbert Habib, Patrizio Lancellotti, Bernard Cosyns, Erwan Donal, Paola Anna Erba, Gilbert Habib, Bernard Iung, Aldo P. Maggioni, Bogdan A. Popescu, Bernard Prendergast, Pilar Tornos, Nora Nabila Ali Tatar-Chentir, Mouaz H. Al‐Mallah, Meriam Åström Aneq, George Athanassopoulos, Luigi P. Badano, S. Benyoussef, Erick Calderón-Aranda, Nuno Cardim, Kwan‐Leung Chan, Bernard Cosyns, Ines Cruz, Thor Edvardsen, Georg Goliasch, Gilbert Habib, Andreas Hagendorff, Krasimira Hristová, Bernard Iung, Otto Kamp, Duk‐Hyun Kang, William Kong, С.Т. Мацкеплишвили, Marwa Meshaal, M Mirocevic, Aleksandar Nešković, Michal Pazdernik, Edyta Płońska‐Gościniak, Bogdan A. Popescu, Bernard Prendergast, Maha Raissouni, Ricardo Ronderos, Leyla Elif Sade, Anita Sadeghpour, Antonia Sambola, Shantanu Sengupta, Jadranka Šeparović Hanževački, Masaaki Takeuchi, Edwin S. Tucay, Ana Clara Tude Rodrigues, Albert Varga, Jolanta Justina Vaškelytė, Kentaro Yamagata, Kyriakos Yiangou, Hosam Zaky, Ricardo Ronderos, Gustavo Avegliano, P. Fernandez Oses, Eduardo Filipini, Isabel Granada, Ana Iribarren, M Mahia, F Nacinovich, S Ressi, R Obregon, M Bangher, J Dho, Luis R Cartasegna, M. Plastino, V Novas, C Shigel, Graciela Reyes, M De Santos, Natalio Gastaldello, M Granillo Fernandez, M Potito, Gisela Streitenberger, P Velazco, José Casabé, Claudia P. Cortés, Eduardo Guevara, Fabián Salmo, M Seijo, Franz Weidinger, Maria Heger, Renee L. Brooks, Claudia Stöllberger, Carolyn Y. Ho, Leonard Perschy, L Puskas, Georg Goliasch, Christian Binder, Raphaël Rosenhek, M Schneider, M-P Winter, E Hoffer, M Melissopoulou, E Lecoq, D. Legrand, Sandrine Jacquet, M Massoz, Patrizio Lancellotti, Luc Piérard, Raluca Dulgheru, Stella Marchetta, C D ́Emal, Cécile Oury, Bernard Cosyns, Steven Droogmans, D. Kerkhove, Andreea Motoc, D. Plein, B Roosens, L Soens, Caroline Weytjens, I Lemoine, Inez Rodrigus, Bernard P. Paelinck, Bram J. Amsel, Philippe Unger, Déborah Konopnicki, C. Beauloye, Agnès Pasquet, S Pierard, David Vancraeynest, Jean‐Louis Vanoverschelde, F Sinnaeve, José Lázaro Andrade, Ana Clara Tude Rodrigues, Kamila Fernanda Staszko, R Dos Santos Monteiro, Marcelo Haertel Miglioranza, D L Shuha, M Alcantara, V Cravo, L Fazzio, Ana Félix, M Iso, C Musa, Ana Paula dos Reis Velloso Siciliano, Fábio Villaça Guimarães Filho, Juarez R. Braga, Ana Clara Tude Rodrigues, R Silva, F Vilela, Daniela Laranja Gomes Rodrigues, L Silva, Samira Saady Morhy, Cláudio Henrique Fischer, R Silva, Marcelo Luiz Campos Vieira, T Afonso, J. Abreu, Sandra Nívea dos Reis Saraiva Falcão, Valdir Ambrósio Moisés, Agostinho Pinto Gouvêa, G João, Francesco M. Mancuso, C. Silva, Ana Carolina Mello Fontoura de Souza, Cely Saad Abboud, Rodrigo Bellio de Mattos Barretto, A Ramos, Renato Tambellini Arnoni, Jorge Eduardo Assef, Dorival Júlio Della Togna, David Le Bihan, L. Miglioli, A P Romero Oliveira, Roberto Tadeu Magro Kroll, Daniel Cortez, Cláudio Léo Gelape, M d C Peirira Nunes, Teresa Cristina Abreu Ferrari, KL Chan, Kevin A. Hay, V. Le, Mathieu Page, Frédéric Poulin, Claude Sauvé, Karim Serri, Chantal Mercure, J Beaudoin, Philippe Pîbarot, Igal A. Sebag, Lawrence Rudski, G Ricafort, Bruno Baršić, Vladimir Krajinović, Martina Vargović, J Separovic-Hanzevacki, Daniel Lovrić, V Reskovic-Luksic, Josip Vincelj, Sandra Jakšić Jurinjak, V Yiannikourides, Marios Ioannides, Chara Kyriakou, C Pofaides, V Masoura, K Yiangou, Jiří Pudich, Aleš Linhart, Michal Širanec, J Marek, K Blechova, Mirt Kamenik, Michal Pazderník, Radek Pelouch, Zdeněk Coufal, M Mikulica, Martin Gřiva, Eva Jančová, M Mikulcova, M Taborsky, Jan Přeček, Markéta Ječmenová, J Látal, J Widimský, T Butta, S Machacek, R Vancata, Jindřich Špinar, Mária Holická, F Pow Chon Long, N Anzules, Arturo Carpio, G Largacha, Ernesto Peñaherrera, Davide Moreira, E Mahfouz, E Elsafty, Amel M. Soliman, Yazan Zayed, J Aboulenein, M Abdel-Hay, Abdallah Almaghraby, Mahmoud Abdelnaby, Mustafa I. Ahmed, Basma Hammad, Yehia Saleh, Hatice S. Zahran, O Elgebaly, Aly M A Saad, Mohammed Ali, A Zeid, Reham El Sharkawy, Marwa Meshaal, A Al Kholy, Ramy Doss, Dina Osama, Hussien Rizk, A Elmogy, M Mishriky, Patrick Assayag, Safwane El Hatimi, Élisabeth Botelho-Nevers, Saveria Campisi, J-F Fuzellier, Amandine Gagneux‐Brunon, Romain Pierrard, C. Tulane, M Detoc, T Mehalla, D Boutoille, Ousama Al Habash, N Asseray-Madani, Charlotte Biron, Julia Brochard, J. Caillon, C Cueff, Thierry Le Tourneau, Anne-Sophie Lecompte, R. Lecomte, M. Lefèbvre, M. Michel, S. Pattier, S Delarue, M. Le Bras, Jéremie Orain, J-F Faucher, Victor Aboyans, A Beeharry, H. Durox, Maximiliano Otero Lacoste, Julien Magné, Dania Mohty, Anthony S. David, V. Pradel, Victor Sierra, A. Neykova, B Bettayeb, S Elkentaoui, B. Tzvetkov, Gregory J. Landry, C. Strady, K Ainine, S. Baumard, Camille Brasselet, C Tassigny, V Valente-Pires, Marie‐Paule Lefranc, Bruno Hoën, Benjamin Lefèvre, Elodie Curlier, C Callier, N Fourcade, Yannick Jobic, S Ansard, Rozenn Le Berre, Philippe Roux, Florent Le Ven, M-C Pouliquen, Gemma Prat, F Bouchart, A. Savouré, C. Alarçon, C. Chapuzet, I. Gueït, C Tribouilloy, Yohann Bohbot, Fanny Peugnet, Mesut Gun, B Iung, Xavier Duval, X. Lescure, Emila Ilic-Habensus, Nicolas Sadoul, Christine Selton‐Suty, François Alla, Elodie Chevalier, François Goehringer, Olivier Huttin, Rosa García, V Le Marcis, Pierre Tattevin, E Donal, Erwan Flécher, Matthieu Revest, Gilbert Habib, S. Hubert, J-P Casalta, Frédérique Gouriet, Florent Arregle, Serge Cammilleri, Laurent Tessonnier, Alberto Ribéri, C. Chirouze, Kévin Bouiller, A-S Brunel, Pierre‐Edouard Fournier, Laurent Hustache‐Mathieu, Timothée Klopfenstein, J Moreau, Pitt Lim, Léopold Oliver, Julien Ternacle, Amina Moussafeur, P. Chavanet, Lionel Piroth, M. Buisson, Sophie Mahy, Carolina Castro Martins, A Salmon-Rousseau, Sandrine Gohier, C. Piper, Jochen Börgermann, Denise Guckel, D Horstkotte, B Brockmeier, Eliane Roseli Winkelmann, Andreas Hagendorff, Douglas Grey, Georg Nickenig, Robert Schueler, Cihat Öztürk, Elisabeth Stöhr, Christian W. Hamm, Thomas Walther, Reynaldo André Brandt, A-C Frühauf, Christine Hartung, Clara Hellner, C. Wild, Miriam Becker, Satoshi Hamada, W. Kaestner, Karl Stangl, Fabian Knebel, Gerd Baldenhofer, Anna Brecht, Henryk Dreger, C Isner, Frieder Pfäfflin, Miriam Stegemann, Ralf Zahn, B. Fraiture, Caroline Kilkowski, A-K Karcher, S Klinger, H Tolksdorf, Dimitris Tousoulis, Constadina Aggeli, G. Sarri, Skevos Sideris, Erifili Venieri, George Athanassopoulos, Dimitris Tsiapras, I Armenis, A Koutsiari, G Floros, C. Grassos, Stylianos Dragasis, Lοukianos S. Rallidis, Charalampos Varlamos, Lampros K. Michalis, Katerina Κ. Naka, Aris Bechlioulis, Anna Kotsia, Λάμπρος Λάκκας, Κωνσταντίνος Παππάς, Constantinos Papadopoulos, S Kiokas, Athina Lioni, S Misailidou, John Barbetseas, Μaria Bonou, Chris J. Kapelios, I Tomprou, Kanella Zerva, Athanasios Manolis, E. Hamodraka, Dimitrios Athanasiou, G Haralambidis, L Poulimenos, H Samaras, A Nagy, Andrea Bartykowszki, Edit Gara, Shantanu Sengupta, Kunda Mungulmare, Ravi R. Kasliwal, Manish Bansal, A Bhan, S Ranjan, Majid Kyavar, Majid Maleki, F Noohi Bezanjani, Anita Sadeghpour, Azin Alizadehasl, Shabnam Boudagh, A Ghavidel, Pardis Moradnejad, Hamid Reza Pasha, Behshid Ghadrdoost, Dan Gilon, Jacob Strahilevitz, Sarah Israel, Maor Wanounou, Carlo D’Agostino, Paolo Colonna, Lucrezia De Michele, F Fumarola, M Stante, N Marchionni, Valentina Scheggi, B Alterini, Stefano Del Pace, Pierluigi Stefàno, Clotilde Sparano, L P Badano, Denisa Muraru, N Ruozi, R Tenaglia, Ugo Limbruno, Alberto Cresti, Pasquale Baratta, Marco Solari, Cristina Giannattasio, Antonella Moreo, Benedetta De Chiara, Beatriz Montero, F Musca, C A Orcese, Francesca Panzeri, Claudio Russo, F. Spano, Ottavio Alfieri, Michele De Bonis, Eustachio Agricola, Elena Busnardo, Silvia Carletti, Barbara Castiglioni, Stefania Chiappetta, Benedetto Del Forno, David Ferrara, Monica Guffanti, Giuseppe Iaci, E Lapenna, Teodora Nisi, Chiara Oltolini, U. Pajoro, Renée Pasciuta, Marco Ripa, Paolo Scarpellini, Chiara Tassan Din, Roberta Meneghin, Davide Schiavi, Federico Piscione, Rodolfo Citro, Rossella Maria Benvenga, Luigi Greco, Cristina Prota, I Radano, L Soriente, Michele Bellino, Davide Di Vece, Francesco Santini, Antonio Salsano, G M Olivieri, F Turrini, R Messora, Stefano Tondi, Andreea Olaru, Virginia Agnoletto, L Grassi, Claudia Leonardi, S Sansoni, Stefano del Ponte, Guglielmo Mario Actis Dato, Andrea De Martino, Nobuyuki Ohte, Shohei Kikuchi, Kazuaki Wakami, Kazutaka Aonuma, Yu Bin Seo, Tomoko Ishizu, Tomoko Machino‐Ohtsuka, Masae Yamamoto, N Iida, Hidemitsu Nakajima, Yu Nakagawa, Chisato Izumi, Masashi Amano, Makoto Miyake, Kosuke Takahashi, Ichiro Shiojima, Yoko Miyasaka, Hirofumi Maeba, Yoshinobu Suwa, Naoyuki Taniguchi, Satoshi Tsujimoto, Takeshi Kitai, Masao Ôta, Satoshi Yuda, S Sasaki, N Hagiwara, K Yamazaki, K Ashihara, K Arai, Chihiro Saitou, S Saitou, G Suzuki, Yuichi Shibata, Naoki Watanabe, Shun Nishino, Kohei Ashikaga, Nagato Kuriyama, Keitaro Mahara, Kyohei Abe, H Fujimaki, Takashi Okubo, Hidemasa Shitan, S Takanashi, M Terada, Haruko Yamamoto, Masafumi Sata, Hirotsugu Yamada, Kenya Kusunose, Yasuaki Saijo, Haruo Seno, O Yuichiro, Yukio Sakata, Hiroya Mizuno, Satoshi Nakatani, T Onishi, K. Sengoku, Francesco Sera, Seung Woo Park, K Eun Kyoung, L Ga Yeon, J-w Hwang, C Jin-Oh, S-J Park, L Sang-Chol, C Sung-A, Se Yong Jang, D-H Kang, Ran Heo, Sak Lee, J-M Song, E. Jung, Jurgita Plisienė, A Dambrauskaite, G Gruodyte, Regina Jonkaitienė, J Vaskelyte, Vaida Mizarienė, J Atkocaityte, Rūta Žvirblytė, Rouguiatou Sow, A. Codreanu, E Chamorro-De Vega, C. Michaux, T. Staub, L Jacobs-Orazi, C. Mallia Azzopardi, Robert G. Xuereb, T. Piscopo, David Borg, Ramon Casha, James Farrugia, M Fenech, E Pllaha, Ciro Vella, Kazufumi Yamagata, L Grib, Elena Raevschi, A Grejdieru, Gheorghe G. Balan, I Cardaniuc, L Cardaniuc, V Corcea, A Feodorovici, V Gaina, L Girbu, Pavlina Jimbei, D Kravcenco, E Panfile, E Prisacari, E Samohvalov, S Samohvalov, N Sceglova, I Benesco, V Marian, N Sumarga, M Mirocevic, B Božović, Nebojša Bulatović, P Lakovic, Ljilja Musić, Jolien W. Roos‐Hesselink, Ricardo P.J. Budde, T Gamela, Ali R. Wahadat, Otto Kamp, T Meijers, Joost P. van Melle, Vincent M. van Deursen, Harry J.G.M. Crijns, S Bekkers, Emile C. Cheriex, M Gilbers, Bas Kietselaer, Christian Knackstedt, Roberto Lorusso, Simon Schalla, S Streukens, S Chamuleau, M-J Cramer, Arco J. Teske, T Van der Spoel, A Wind, O Liesbek, J Lokhorst, H Van Heusden, Wilco Tanis, Ivo van der Bilt, Joris W.J. Vriend, H De Lange-van Bruggen, E Karijodikoro, Robert K. Riezebos, Elise van Dongen, J Schoep, V Stolk, Olivier Axler, Florian Baumann, S Lebras, Thor Edvardsen, J T Offstad, J O Beitnes, Thomas Helle-Valle, Helge Skulstad, Rita Skårdal, Nadeem Qamar, Shumaila Furnaz, Bina Ahmed, M H Butt, M F Khanzada, Tahir Saghir, A Wahid, T Hryniewiecki, Piotr Szymański, Karolina Marzec, M Misztal-Ogonowska, Wojciech Kosmala, M Przewlocka-Kosmala, Amanda Rojek, K Woznicka, J Zachwyc, Anna Lisowska, M. Kamińska, Jarosław D. Kasprzak, Ewelina Kowalczyk, D F Strzecka, Paulina Wejner‐Mik, M Trabulo, P Freitas, Sara Ranchordás, Gabriel Rodrigues, Patrícia Pinto, Catarina Queirós, J Azevedo, L Marques, Daniel Seabra, Luísa Moura Branco, J. Abreu, Madalena Coutinho Cruz, A Galrinho, Rita Ilhão Moreira, Pedro Rio, Ana Teresa Timóteo, Mafalda Selas, Nuno Cardim, Vanda Carmelo, Bernardo Neves, Henrique Pereira, I Cruz, Andrea Guerra, A Marques, I Pintassilgo, Mirela Tomescu, N-M Trofenciuc, Minodora Andor, A Bordejevic, H S Branea, Florin Alexandru Căruntu, Liviu Cirin, Ioana Mihaela Citu, Coralia Cotoraci, D Darabantiu, R. Farcas, Iosif Marincu, Adelina Mavrea, Mustafa Önel, T Parvanescu, Dana Pop, Adina Pop‐Moldovan, M I Puticiu, L A Velcean, A. Ionac, Dragoș Cozma, Cristian Mornoş, F Goanta, I Popescu, Ruxandra Beyer, Razvan O. Mada, Raluca Rancea, Ştefan Horia Roşian, Raluca Tomoaia, Cristina Stănescu, Zhanna Kobalava, J Karaulova, E. O. Kotova, A Milto, A Pisaryuk, N Povalyaev, Maria Sorokina, Jamilah AlRahimi, A Elshiekh, Abdulrahman Jamiel, Amjad Ahmed, Mouaz H. Al‐Mallah, N. Attia, B Putnikovic, Aleksandar Nešković, Andreja Dimić, Branislava Ivanović, S Matić, D Trifunovic, Jelena Petrović, D Kosevic, P Dabic, Predrag Milojević, Ivana Petrović, Ivana Stojanović, Ilija Srdanović, M Kovacević, Aleksandar Redžek, Maja Stefanović, S Susak, Lazar Velicki, Aleksandra Vulin, Tiong Cheng Yeo, William Kong, Kian Keong Poh, Isidre Vilacosta, Mahmoud Abd El-Nasser, C Ferrera, Carmen Olmos, Francisco Calvo, E Blanco-Gonzalez, M Bravo Amaro, A. Nodar Germiñas, E Lopez-Rodriguez, J Lugo Adan, Pablo Pazos-López, M Pereira Loureiro, Maria T. Perez, Sergio Raposeiras‐Roubín, S Rasheed Yas, M-M Suarez-Varela, F Vasallo Vidal, David García‐Dorado, Antonia Sambola, Nuria Fernández‐Hidalgo, Teresa González‐Alujas, J Lozano, Olga Maisterra, Natalia Pizzi, Raquel Ríos, P. Tornos, Antoni Bayés‐Genís, L Pedro Botet, Núria Vallejo, E. 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Sanz, Graciano García‐Pardo, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, L Abid, Rania Hammami, S. Kammoun, Mohamed Sami Mourali, F Mghaieth Zghal, Manel Ben Hlima, S. Boudiche, S. Ouali, Lilia Zakhama, S Antit, I. Ben Slama, Okan Gülel, Müjgan Ayşenur Şahin, Leyla Elif Sade, Emir Karaçağlar, S Kucukoglu, Özge Çetinarslan, U S Yasar, Uğur Canpolat, Bülent Mutlu, Hakan Ataş, R Dervishova, Çiğdem İleri, H Zaky, J Alhashmi, F Baslib, J Tahir, P Zarger, Simon Woldman, Luanna Silva Monteiro Menezes, C Primus, Rakesh Uppal, I Bvekerwa, Badrinathan Chandrasekaran, A Kopanska, B D Prendergast, Stefano Cannata, Jeffrey W. Chambers, Jane Hancock, John L. Klein, Ronak Rajani, Maria Paola Ursi, Rafał Dworakowski, A Fife, John Breeze, M Browne-Morgan, M. Gunning, S Streather, Federico M. Asch, M Zemedkun, B. A. Alyavi, Jamol Uzokov · 发表于：European Heart Journal - Quality of Care and Clinical Outcomes · 年份：2025 · DOI：10.1093/ehjqcco/qcaf145 · 被引用次数：1 · 研究领域：Infective Endocarditis Diagnosis and Management、Antimicrobial Resistance in Staphylococcus、Surgical site infection prevention

AIMS: Enterococcal infective endocarditis (EIE) represents a growing proportion of infective endocarditis (IE) cases, particularly among elderly and comorbid patients. EIE poses diagnostic and therapeutic challenges, notably regarding optimal antimicrobial therapy and surgical decision-making. We aimed to compare the clinical characteristics, management, and outcomes of EIE vs. non-enterococcal IE (NEIE) in the ESC-EORP EURO-ENDO registry. METHODS AND RESULTS: This ancillary analysis of the prospective EURO-ENDO registry included adult patients with definite or possible IE enrolled between January 2016 and March 2018. Patients with monomicrobial EIE were compared with those with NEIE. Clinical, microbiological, imaging, and therapeutic data were analysed. Multivariable logistic regression including EuroSCORE II and valve status identified independent predictors of in-hospital mortality. Among 3083 patients, 365 (12%) had monomicrobial EIE. Compared with NEIE, EIE patients were older (mean 68 vs. 58 years), had more comorbidities, and more frequent prosthetic valve involvement (41% vs. 26%). Aortic valve localization and colonic uptake on PET/CT were also more common. In-hospital mortality was similar (16% vs. 17%). After adjustment for EuroSCORE II and valve status, EIE was not independently associated with higher in-hospital mortality (adjusted OR 0.67 [95% confidence interval 0.42-1.04]; P = 0.083). Among 195 EIE patients with 1-year follow-up, recurrence occurred in 6%. He...