Data from Loss of PTEN Expression, PIK3CA Mutations, and Breast Cancer Survival in the Nurses’ Health Studies

作者：Tengteng Wang, Yujing J. Heng, Gabrielle M. Baker, Vanessa C. Bret-Mounet, Liza M. Quintana, Lisa Frueh, Susan E. Hankinson, Michelle D. Holmes, Wendy Y. Chen, Walter C. Willett, Bernard Rosner, Rulla M. Tamimi, A. Heather Eliassen · 年份：2025 · DOI：10.1158/1055-9965.c.8169964 · 研究领域：PI3K/AKT/mTOR signaling in cancer、Biological Research and Disease Studies、Cancer Risks and Factors

<div>AbstractBackground:The relationships between PTEN loss and/or PIK3CA mutation and breast cancer prognosis remain controversial. We aim to examine the associations in large epidemiologic cohorts.Methods:We followed women with invasive breast cancer from the Nurses’ Health Studies with available data on tumor PTEN expression (n = 4,111) and PIK3CA mutation (n = 2,930). PTEN expression was evaluated by IHC and digitally scored (0%–100%). Pyrosequencing of six hotspot mutations of PIK3CA was performed.Results:We found loss of PTEN expression (≤10%) occurred in 17% of cases, and PIK3CA mutations were detected in 11% of cases. After adjusting for clinical and lifestyle factors, PTEN loss was not associated with worse breast cancer-specific mortality among all samples [HR, 0.85; 95% confidence intervals (CI), 0.71–1.03] or among estrogen receptor (ER)-positive tumors (HR, 0.99; 95% CI, 0.79–1.24). However, among ER-negative tumors, PTEN loss was associated with lower breast cancer-specific mortality (HR, 0.68; 95% CI, 0.48–0.95). PIK3CA mutation was not strongly associated with breast cancer-specific mortality (HR, 0.89; 95% CI, 0.67–1.17). Compared with tumors without PTEN loss and without PIK3CA mutation, those with alterations (n = 540) were not at higher...

Data from Loss of PTEN Expression, &lt;i&gt;PIK3CA&lt;/i&gt; Mutations, and Breast Cancer Survival in the Nurses’ Health Studies

Data from Loss of PTEN Expression, <i>PIK3CA</i> Mutations, and Breast Cancer Survival in the Nurses’ Health Studies