A Review of Differential Plant Responses to Drought, Heat, and Combined Drought + Heat Stress

作者：Ning Li, Zhi Geng, Xiaodong Huang, Shunqi Huang, Lulu Song, Ruirui Chen, Ziping Chen, Longmeng Du, Congshan Xu · 发表于：Current Issues in Molecular Biology · 年份：2025 · DOI：10.3390/cimb47120975 · 被引用次数：14 · 研究领域：Plant Molecular Biology Research、Plant Stress Responses and Tolerance、Insect-Plant Interactions and Control

Global warming increases the frequency with which drought and heat stress occur simultaneously, especially in semi-arid regions. Such combined stress imposes a non-additive and more severe impact on plant growth, yield, and quality than either stress alone. Here, we integrate recent physiological, biochemical, and multi-omics studies to compare individual and combined stress responses and to dissect the underlying signal transduction networks. We show that drought-dominated phases rapidly elevate ABA concentrations and activate SnRK2-AREB cascades, whereas heat pulses trigger jasmonic acid and ethylene signals that antagonize ABA-driven stomatal closure. Under combined stress, these hormonal modules converge on a "competitive TF marketplace", where ABA, JA, and GA cis-elements co-regulate invertase-sugar checkpoints, heat shock factor/ROS oscillators, and chromatin-remodeling events that determine reproductive fate. Recent advances using multi-omics approaches and systems biology have further elucidated these complex networks. These insights will inform future breeding strategies aiming to develop stress-tolerant crops. We highlight emerging tools-weighted gene co-expression networks, kinetic multi-omics, and cis-regulatory CRISPR editing-that can exploit these signaling hubs for breeding crops with improved combined stress tolerance.