Engineering an antibacterial gel-forming adhesive powder for emergency hemostasis and wound healing

作者：Kaiwen Zhang, Y Chen, Gang He, Yiwen Xian, Yu Yang, Chong Zhang, Decheng Wu · 发表于：Cell Reports Physical Science · 年份：2025 · DOI：10.1016/j.xcrp.2025.102978 · 被引用次数：3 · 研究领域：Hemostasis and retained surgical items、Wound Healing and Treatments、Antimicrobial agents and applications

Current powdered hemostats often fail to control lethal non-compressible hemorrhage due to slow clotting, poor adhesion, potential cytotoxicity, and limited antibacterial activity. Herein, we engineer an antibacterial gel-forming adhesive powder (SLC) composed of tetra-armed poly(ethylene glycol) succinimidyl succinate (Tetra-PEG-SS), ε-polylysine (EPL), and chitosan microspheres (CMs). Upon application, CMs rapidly absorb blood and accelerate clotting, while hydration induces covalent crosslinking to form a robust adhesive hydrogel seal. The optimized SLC exhibits high fluid absorption, strong tissue adhesion, rapid clotting, satisfactory burst pressure, potent antibacterial activity, and favorable biocompatibility. In rat models, SLC outperforms commercial powdered hemostats in hemostatic efficacy. It also achieves effective hemostasis in porcine liver, spleen, and femoral artery injury models. Additionally, SLC accelerates skin defect repair in rats by reducing inflammation, enhancing collagen deposition, and promoting angiogenesis. These findings highlight the potential of SLC as an advanced hemostat for lethal hemorrhage control, wound healing, and infection prevention.